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FRI0523 Clinical Value of Serum Anti-C1Q Antibodies as a Marker for Nephritis Activity in Pediatric Patients with SLE in Comparison to Anti-DSDNA
  1. M. Helal1,
  2. N.A.E.M. Hussein1,
  3. M.M.E.D. El Kersh2,
  4. D.M.F. Mohaseb1,
  5. M.M. El Bardawil1,
  6. M.M. El Sawy3
  1. 1Rheumatology
  2. 2Pediatric
  3. 3Clinical Pathology, Alexandria University, Alexandria, Egypt

Abstract

Background Autoantibodies against C1q (anti-C1q) have been described a lot in adult patients with systemic lupus erythromatosus (SLE), where they were strongly significant with the occurrence of severe lupus nephritis (LN). However, due to the few clinical studies held in the field of pediatric rheumatology its role has not been well determined in children with systemic lupus erythromatosus.

Objectives To evaluate serum anti-C1q antibodies in pediatric systemic lupus erythromatosus (pSLE) to determine its clinical and statistical association in nephritis activity in comparison to anti-dsDNA

Methods Sera from 44 pSLE patients and 30 healthy individuals were collected. Anti-C1q, Anti-dsDNA, ANA, were measured by enzyme-linked immunosorbant assays. Patient records were evaluated for clinical and laboratory associations

Results Anti-C1q antibodies were more prevalent than anti-ds DNA (n=41,93.2%)in pSLE patients of the current study, which correlated significantly with proteinuria and decreased complement levels (p<0.05). Anti-C1q levels were significantly elevated in patients with class III/IV nephritis compared II/V nephritis. pSLE patients with active nephritis at the time of sample collection demonstrated significantly elevated levels of anti-C1q antibodies compared to those without active nephritis. Anti-C1q antibodies were more sensitive and specific than anti-dsDNA in pSLE patients

Conclusions This study indicates the importance of measuring anti-C1q antibodies in pSLE patients because elevated anti-C1q antibodies may be more indicative and specific for detecting disease activity, showing significant correlation with proteinuria and active nephritis than anti-DNA antibodies

References

  1. Kozyro I, Perahud I, Sadallah S, et al. Clinical value of autoantibodies against C1q in children with glomerulonephritis. Pediatrics. 2006;117(5):1663-8

  2. Salah M, Abdel Kader M, Abd Elaziz M, Hisham M. Role of serum anti-C1q antibodies as a biomar ker for nephritis activity in pediatric and adolescent Egyptian female patients with SLE. Expert Opin. Med. Diagn; 2012 (6):489-498

  3. Eggert M, Zettl UK, Neeck G. Autoantibodies in autoimmune diseases. Curr Pharm Des 2010;16:1634-43.

  4. Pickering MC, Botto M. Are anti-C1q antibodies different from other SLE autoantibodies? Nat Rev Rheumatol 2010;6:490-3.

Acknowledgements I would like to thank all my supervisors for thier expert advice and encouragement through out this study

Disclosure of Interest None declared

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