Platelets are anucleated blood element highly potent at generating extracellular vesicles (EV) called microparticles (MPs). While EVs appear as an important means of intercellular communication, the complexity of the platelet MP cargo is starting to be delineated. Studies show that platelet MPs express a broad repertoire of nucleic acid (eg microRNA), transcription factors and organelles, such as respiratory-competent mitochondria. The MP cargo can be internalized into cells thereby modifying the recipient activity. Furthermore, mitochondria are thought to originate from the endosymbiosis of the Alphaproteobacterium Rickettsia prowazekii during the development of the eukaryotic cells. As mitochondria are released concomitantly with MPs from activated platelets, they can trigger highly potent pro-inflammatory signals. The platelet MP cargo is thus complex, and its contribution to pathology in rheumatic diseases must be considered.
Disclosure of Interest None declared
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