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FRI0425 The Global Antiphospholipid Syndrome Score (GAPSS) Differentiates Between Transient Ischemic Attack and Stroke in Patients with Antiphospholipid Antibodies
  1. S. Sciascia1,
  2. G. Sanna1,
  3. V. Murru1,
  4. D. Roccatello2,
  5. M. Khamashta1,
  6. M.L. Bertolaccini3
  1. 1Louise Coote Lupus Unit, Guy's and St Thomas' NHS Foundation Trust, St Thomas' Hospital, London, United Kingdom
  2. 2Centro di Ricerche di Immunologia Clinica ed Immunopatologia e Documentazione su Malattie Rare (CMID), Torino, Italy
  3. 3Graham Hughes Lupus Research Laboratory, Lupus Research Unit, The Rayne Institute, Division of Women's Health, King's College London, London, United Kingdom

Abstract

Background Arterial event are frequent in the antiphospholipid syndrome (APS) and stroke is a major clinical manifestation of syndrome. Recently, we conducted a study in a large cohort of Systemic Lupus Erythematosus (SLE) patients applying a risk score for APS clinical manifestations (Global APS Score or GAPSS), demonstrating that risk profile for APS can be successfully assessed.

Objectives In this study, we aimed to evaluate the clinical usefulness of the GAPSS in differentiating between transient ischemic attack (TIA) and stroke in a cohort of patients tested positive for aPL who sufferedcerebrovascular ev

Methods We included 40 consecutive SLE patients attending the Louise Coote Lupus Unit at St Thomas Hospital, London, all with a history of cerebravoscular events. Demographic, clinical and laboratory characteristics were collected. aPL profile included anticardiolipin antibodies (aCL), lupus anticoagulant (LA), anti β2 glycoprotein I antibody (anti-β2GPI), and antibodies to phosphatidylserine-prothrombin complex (aPS/PT). Cardiovascular risk factors were assessed following NICE guidelines. The GAPSS system was calculated for each patient

Results Nineteen patients (47.5%) had stroke, 16 (40%) a transient ischemic attack (TIA), defined as neurologic symptoms or signs lasting less than 24 hours by a neurologist. Five patients (12.5%) experienced both. Thirty patients (75%) fulfilled the current APS classification criteria. Higher values of GAPSS were seen in patients who experienced stroke (alone or in association with TIA) when compared to those with TIA alone (10.13±3.3 [range 5-16] vs. 6.3±4.6 [range 3-13], p=0.033). This observation was confirmed when compared patients who had a history of stroke alone with patients with TIA alone (9.95±3.29 [range 5-16] vs. 6.3±4.6 [range 3-13], p=0.029). Patients who experienced both stroke and TIA showed the highest GAPSS but the difference was only statistically significant when compared to those with TIA alone (10.8±3.63 [range 7-16] vs. 6.3±4.6 [range 3-13], p=0.03).

Conclusions GAPSS is a valid tool for risk stratification for ischemic manifestation in the setting of cerebrovascular events. This tool may help identifying a more “at risk” population in whom a tailored prophylaxis therapy might be beneficial.

Disclosure of Interest None declared

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