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FRI0307 Bone Mineral Density, Spinal Micro-Architecture (TBS Data) and Body Composition in the Older Ukrainian Women with Vertebral Fragility Fractures
  1. V. Povoroznyuk,
  2. N. Dzerovych,
  3. R. Povoroznyuk
  1. Institute of Gerontology Nams Ukraine, Kyiv, Ukraine

Abstract

Background Osteoporosis and sarcopenia are the most frequent musculoskeletal disorders affecting older people. Fracture incidence as well as the number of fractures increase due to the population's ageing. Recent studies show that a low skeletal muscle mass is associated with the poor structural bone parameters and impaired balance of the elderly people.

Objectives The aim of this study is to evaluate the bone mineral density (BMD), trabecular bone score (TBS) and body composition in women taking into account the presence of vertebral fragility fractures (VFF).

Methods We've examined 171 women aged 65-89 years (mean age – 73.12±0.39 yrs; mean height – 1.58±0.004 m; mean weight – 72.54±0.99 kg). The patients were divided into the groups depending on the VFF presence: A – no VFF (n=105; mean age – 72.70±0.54 yrs; mean height – 1.58±0.006 m; mean weight – 74.43±1.33 kg), B – present VFF (n=66; mean age – 73.79±0.55 yrs; mean height – 1.58±0.008 m; mean weight – 69.53±1.37 kg). Total body, lumbar spine, femoral neck, forearm BMD, lateral vertebral assessment, trabecular bone score (L1-L4), lean and masses were measured by DXA densitometer (Prodigy, GE). Appendicular skeletal mass (ASM) was measured at all the four limbs with DXA. We've also calculated the appendicular skeletal mass index (ASMI) according to the formula ASM/height2 (kg/m2).

Results We have found the following parameters to be significantly lower in women with the VFF compared to women having no VFF:

BMD of total body (A – 0.859±0.01 g/cm2, B – 0.764±0.02 g/cm2; p<0.05), spine (A – 1.038±0.02 g/cm2, B – 0.927±0.03 g/cm2; p<0.05), femoral neck (A – 0.787±0.01 g/cm2, B – 0.711±0.01 g/cm2; p<0.05), 33% forearm (A – 0.690±0.01 g/cm2, B – 0.600±0.01 g/cm2; p<0.05), TBS (A – 1.171±0.01, B – 1.116±0.02; p<0.05), whole-body fat mass (A – 30736.87±939.92 g, B – 25877.45±966.90 g; p<0.05), whole-body lean mass (A – 41202.44±498.18 g, B – 39440.77±594.78 g; p<0.05), ASM (A – 16.47±0.22 kg, B – 15.81±0.22 kg; p<0.05) and ASMI (A – 6.59±0.07 kg/m2, B – 6.34±0.09 kg/m2; p<0.05). The frequency of sarcopenia was 2% in women with no VFF and 14% - in women with the VFF.

Conclusions Women with the VFF have the BMD, TBS, lean and fat masses data significantly lower in comparison to women with no VFF.

Disclosure of Interest None declared

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