Article Text

PDF
FRI0299 Prevalence of Vertebral Fractures in Osteoporotic HIP Fractured Patients: The Focus Study
  1. G. Arioli1,
  2. P. Falaschi2,
  3. G. Letizia Mauro3,
  4. G. Iolascon4,
  5. M. Invernizzi5,
  6. M. Noale6,
  7. M. Manfredini1,
  8. G. Bernardi1,
  9. C. Cisari5
  1. 1Department of Neurosciences, Hospital “Carlo Poma”, Mantova
  2. 2Geriatric Unit, “Sapienza” University of Rome, S. Andrea Hospital, Rome
  3. 3Department of Rehabilitation, University of Palermo, Palermo
  4. 4Department of Medical and Surgical Specialties and Dentistry, Second University of Naples, Naples
  5. 5Physical and Rehabilitative Medicine, Department of Health Sciences, University of Eastern Piedmont “A. Avogadro”, Novara
  6. 6Neuroscience Institute, Aging Branch, CNR, Padua, Italy

Abstract

Background Osteoporosis is a multifactorial systemic skeletal disease, characterized by low bone mass and microarchitectural modifications of bone tissue, with a consequent increase in fragility fractures [1]. Vertebral fractures are the most prevalent osteoporotic fractures and osteoporotic hip fractures are the most serious complication of osteoporosis resulting in increased mortality and high socio-economic cost [2,3]. The coexistence of these two pathological conditions in elderly patients has been previously described, leading to even worse functional outcomes than each one alone [4].

Objectives To determine the prevalence of vertebral fractures in osteoporotic hip fractured women and to evaluate the relationship between prevalence of vertebral fractures and pre-existing factors such us autonomy in daily life activity, quality of walking, numbers of falls, cognitive aspects and comorbidities.

Methods 946 osteoporotic hip fractured women aged more than 60 years and with an X-ray evaluation of spine were consecutively enrolled in 25 Orthopaedic, Physical Medicine and geriatric centers in Italy. After spine X-ray morphometry patients were divided in two groups: previous vertebral fracture (F) and no previous fracture (NF). Moreover anamnestic, demographical and outcome related data (ADL, IADL, CIRS, SPMSQ, FAC and RANKIN scale) were collected.

Results Prevalent vertebral fractures were present in 502 (54%) patients. 119 (13.7%) patients had at least one severe fracture. The F compared to NF group showed statistically significant worse scores regarding the pre hip fracture values of RANKIN, CIRS, SPMSQ, IADL and the overall number of falls (p<0.001). Moreover the F group showed statistically significant lower values of serif 25(OH)D than NF group (p<.0.001).

Conclusions Previous Vertebral fractures in hip fractured patients are a common issue and negatively influence several functional and cognitive outcome measures in these patients.

References

  1. NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis and Therapy. Osteoporosis prevention, diagnosis and therapy. JAMA. 2001;285:785–795

  2. Sattui SE, Saag KG. Fracture mortality: associations with epidemiology and osteoporosis treatment. Nat Rev Endocrinol. 2014 Oct;10(10):592-602.

  3. Svedbom A, Hernlund E, Ivergård M, Compston J, Cooper C, Stenmark J, McCloskey EV, Jönsson B, Kanis JA; EU Review Panel of IOF. Osteoporosis in the European Union: a compendium of country-specific reports. Arch Osteoporos. 2013;8(1-2):137.

  4. Gonnelli S, Caffarelli C, Maggi S et al. The assessment of vertebral fractures in elderly women with recent hip fractures: the BREAK Study. Osteoporosis In.t 2013;24:1151-1159

Disclosure of Interest None declared

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.