Article Text

PDF
FRI0230 The Initial Symptoms of Ankylosing Spondylitis and the HLA-B27 Subtypes
  1. Q. Jun,
  2. P. Zhang,
  3. Z. Lin,
  4. J. Gu
  1. Department of Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

Abstract

Background Different subtypes of HLA-B27 have a special positive association with some clinical features of AS.HLA-B*2705-positive patients had a higher incidence of uveitis.however,whether AS patients with different HLA-B27 subtypes have different initial symptoms is not clear.

Objectives This study aimed to investigate the association between the initial symptoms and the HLA-B27 subtypes.

Methods This study included 476 patients with AS. Direct sequencing was used to identify the HLA-B27 genotype. Clinical parameters, including initially affected sites, were compared among patients with various HLA-B27 subtypes.

Results Out of 476 patients, 437 AS patients (91.8%) were HLA-B27-positive. The most prevalent subtypes were HLA-B*2704 (90%) and HLA-B*2705 (8.6%) in patients with AS. Initially affected sites such as axial joint (54.5% and 55.3%) and peripheral joint (35.9% and 31.6%) were most common between HLA-B*2704-positive patients and HLA-B*2705-positive patients. There were no significant differences in initially affected sites such as axial joint, peripheral joint, hip joint, axial joint+ peripheral joint, axial joint+hip, or peripheral joint+ hip among above groups. Compared with HLA-B*2704-positive patients, HLA-B*2705- patients demonstrated a significant increase in the incidence of uveitis (initial symptom, 5.3% vs. 0.5%, P=0.041).

Conclusions Specific HLA-B27 subtypes were positively associated with particular initial symptoms. Uveitis was more frequent as an initial symptom in HLA-B*2705-positive patients than HLA-B*2704-positive patients did.

References

  1. Qi J, Li Q, Lin Z, et al. Higher risk of uveitis and dactylitis and older age of onset among ankylosing spondylitis patients withHLA-B*2705than patients withHLA-B*2704in the Chinese population. Tissue antigens. 2013;82(6):380-386

  2. Braakenburg AM, de Valk HW, de Boer J, Rothova A. Human leukocyte antigen-B27-associated uveitis: long-term follow-up and gender differences. Am J Ophthalmol 2008: 145: 472–9.

Disclosure of Interest None declared

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.