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FRI0230 The Initial Symptoms of Ankylosing Spondylitis and the HLA-B27 Subtypes
  1. Q. Jun,
  2. P. Zhang,
  3. Z. Lin,
  4. J. Gu
  1. Department of Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China


Background Different subtypes of HLA-B27 have a special positive association with some clinical features of AS.HLA-B*2705-positive patients had a higher incidence of uveitis.however,whether AS patients with different HLA-B27 subtypes have different initial symptoms is not clear.

Objectives This study aimed to investigate the association between the initial symptoms and the HLA-B27 subtypes.

Methods This study included 476 patients with AS. Direct sequencing was used to identify the HLA-B27 genotype. Clinical parameters, including initially affected sites, were compared among patients with various HLA-B27 subtypes.

Results Out of 476 patients, 437 AS patients (91.8%) were HLA-B27-positive. The most prevalent subtypes were HLA-B*2704 (90%) and HLA-B*2705 (8.6%) in patients with AS. Initially affected sites such as axial joint (54.5% and 55.3%) and peripheral joint (35.9% and 31.6%) were most common between HLA-B*2704-positive patients and HLA-B*2705-positive patients. There were no significant differences in initially affected sites such as axial joint, peripheral joint, hip joint, axial joint+ peripheral joint, axial joint+hip, or peripheral joint+ hip among above groups. Compared with HLA-B*2704-positive patients, HLA-B*2705- patients demonstrated a significant increase in the incidence of uveitis (initial symptom, 5.3% vs. 0.5%, P=0.041).

Conclusions Specific HLA-B27 subtypes were positively associated with particular initial symptoms. Uveitis was more frequent as an initial symptom in HLA-B*2705-positive patients than HLA-B*2704-positive patients did.


  1. Qi J, Li Q, Lin Z, et al. Higher risk of uveitis and dactylitis and older age of onset among ankylosing spondylitis patients withHLA-B*2705than patients withHLA-B*2704in the Chinese population. Tissue antigens. 2013;82(6):380-386

  2. Braakenburg AM, de Valk HW, de Boer J, Rothova A. Human leukocyte antigen-B27-associated uveitis: long-term follow-up and gender differences. Am J Ophthalmol 2008: 145: 472–9.

Disclosure of Interest None declared

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