Background Different subtypes of HLA-B27 have a special positive association with some clinical features of AS.HLA-B*2705-positive patients had a higher incidence of uveitis.however,whether AS patients with different HLA-B27 subtypes have different initial symptoms is not clear.
Objectives This study aimed to investigate the association between the initial symptoms and the HLA-B27 subtypes.
Methods This study included 476 patients with AS. Direct sequencing was used to identify the HLA-B27 genotype. Clinical parameters, including initially affected sites, were compared among patients with various HLA-B27 subtypes.
Results Out of 476 patients, 437 AS patients (91.8%) were HLA-B27-positive. The most prevalent subtypes were HLA-B*2704 (90%) and HLA-B*2705 (8.6%) in patients with AS. Initially affected sites such as axial joint (54.5% and 55.3%) and peripheral joint (35.9% and 31.6%) were most common between HLA-B*2704-positive patients and HLA-B*2705-positive patients. There were no significant differences in initially affected sites such as axial joint, peripheral joint, hip joint, axial joint+ peripheral joint, axial joint+hip, or peripheral joint+ hip among above groups. Compared with HLA-B*2704-positive patients, HLA-B*2705- patients demonstrated a significant increase in the incidence of uveitis (initial symptom, 5.3% vs. 0.5%, P=0.041).
Conclusions Specific HLA-B27 subtypes were positively associated with particular initial symptoms. Uveitis was more frequent as an initial symptom in HLA-B*2705-positive patients than HLA-B*2704-positive patients did.
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Disclosure of Interest None declared