Osteoarthritis is a heterogeneous disease affecting predominantly knees, hands and hips. The burden of disease for patients with osteoarthritis is considerable. Currently, the treatment for osteoarthritis is focused on alleviation of symptoms, such as pain, stiffness and disability. Both non-pharmacological interventions, such as education strategies, exercise therapy, assistive technology and weight loss, and pharmacological interventions, such as paracetamol and topical and oral NSAIDs, have been investigated for that purpose and evidence for their efficacy is available. For many years treatment to modify the disease course of osteoarthritis have been sought and investigated. New developments have elucidated that not only cartilage loss could be a target for treatment, but also processes going on in other compartments of the joint: the subchondral bone and synovium. Especially subchondral bone activity and synovitis open new possibilities for treatment. Promising treatments to modify the disease are currently investigated.
Disclosure of Interest None declared