Background Familial Mediterranean Fever (FMF) is autosomal ressesive disease which is commonly seen in mediterrenean countries with recurrent episodes of fever, peritonitis, pleuritis, arthritis, or erysipelas-like erythema. Some FMF patients develop sacroilitis and spondyloarthropatis. Ankylosing Spondilitis (AS) is a disease within spondyloarthritis group which is characterized by inflammation of the axial joints, peripheral oligoarthritis, and enthesitis.
Objectives The aim of this study was to provide a comparison between AS patients and FMF with AS patients.
Methods This study includes 360 AS patients and 44 FMF patients with AS. All cases were evaluated retrospectively, and patients' demographic and clinical data, disease activity index, acute phase response, and their recent medications were recorded.
Results Twenty seven out of 44 FMF patients with AS were female, the remaining 17 were male. The mean age was 34.5±8.6years, and the symptoms of onset show that 18 patients had serocytis, 19 patients had arthritis, 7 patients had inflammatory back pain. Out of 360 AS patients, 244 patients were male, 116 patients were female. The mean age of AS patients was 41.2±10.8 years. When all features considered, 328 patients with AS and 44 patients with FMF had inflammatory back pain, 181 patients with AS and 24 patients with FMF had hip pain, 52 patients with AS and 17 patients with FMF had peripheral arthritis, 108 patients with AS and 18 patients with FMF had heel pain, 41 patients with AS and one patients with FMF had uveitis, and 65 patients with AS and 3 patients with FMF had syndesmophyte, 80 patients with AS and 16 patients with FMF had enthesitis on the X-ray (Table 1). No statistically significant difference was observed between when AS patients and FMF patients with AS were compared, except for peripheral arthritis and syndesmofitis.
Conclusions When AS patients and FMF patients with AS were compared, peripheral arthritis and enthesitis were in high frequency, but uveitis and syndesmophyte were less frequent in FMF patients with AS. To obtain scientific significance, there is a need for more results in broader study groups.
Yilmaz Ö, Kısacık B, Ozkan F, Güven G, Unlü EN, Pehlivan Y, Onat AM. Does enthesopathy relate to M694V gene mutation in patients with Familial Mediterranean fever? Clin Rheumatol. 2013;32(11):1593-8.
Akkoc N, Gul A. Familial Mediterranean fever and seronegative arthritis. Curr Rheumatol Rep. 2011;13(5):388-94.
Disclosure of Interest None declared
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