Accelerated atherosclerosis leading to increased cardiovascular (CV) morbidity and mortality has been associated with immune-mediated inflammatory diseses (IMIDs). Systemic inflammation underlying IMIDs, such as rheumatoid arthritis (RA), spondyloarthropathies (SpA), inflammatory bowel diseases (IBD) or psoriasis may be the leading trigger of inflammatory CV disease. Here the major pathogenic pathways involved in IMID-related atherosclerosis, screening and diagnostic methods, prognostic factors, as well as practical recommendations for management and prevention will be discussed. It is important to note that
– CV disease is a crucial comorbidity in IMIDs
– mostly inflammatory mechanisms, but also traditional risk factors have been implicated
– patients with IMID should be regularly screened for CV and metabolic disorders
– various means of prevention should be applied to all patients at high risk
– traditional vasculoprotection is important, however, antirheumatic therapy including biological and concventional DMARDs may have beneficial effects on the vasculature.
Disclosure of Interest None declared