Background Behçet's Disease (BD) is a systemic vasculitis that affects both arterial and venous systems. Endothelial damage and endothelial activation are important steps in the pathogenesis of BH. It was also shown that endothelial activation plays a role in the pathogenesis of other diseases such as systemic lupus erythematosus (SLE). Angiopoietins are angiogenetic factors which are secreted from endothelial cells and are needed for vascular development, maturation and inflammation. Four different angiopoietins (ANG) has been described so far. While ANG-1 suppresses vascular inflammation, ANG-2 stimulates controversially.
Objectives The aims of this study were;
1) To investigate ANG-1 and ANG-2 levels in BH, SLE and healthy controls, and the relationship between the groups
2) To investigate the relationship between ANG-1, ANG-2 levels and BD subtypes.
3) To investigate the relationship between ANG-1, ANG-2 levels and disease activity in BD.
Methods A hundred-one BD patients (according to ISGBD criteria), 65 SLE patients (according to 1987 ACR criteria) and 76 age-sex matched healthy controls were included in the study. Serum ANG levels were determined with ELISA method in all patients and controls. Student's t test and Mann Whitney U test were used for statistical analysis.
Results While, there was a statistically significant difference in serum ANG-2 levels between BH and healthy controls (p=0.039), serum ANG-1 levels were similar in both groups. It was found that ANG-1 levels were higher (p=0.001) and ANG-2 levels were lower (p=0.005) in BD patients when compared to the SLE patients. When SLE and healthy controls are compared, it was seen that ANG-1 levels were lower (p=0.001) and ANG-2 levels were higher (p=0.001) in SLE group. There was no relationship determined between any of the BD subtypes including vascular involvement and ANG levels.
Conclusions According to our results, ANG-2 levels which secreted from endothelial cells might be an important indicator to show endothelial damage in BD and SLE diseases. But no relationship was determined between ANG-1, ANG-2 levels and disease activity nor subtypes of Behçet's Disease.
Fuxe J, Lashnits E, O'Brien S, Baluk P, Tabruyn SP, Kuhnert F, et al. Angiopoietin/Tie2 signaling transforms capillaries into venules primed for leukocyte trafficking in airway inflammation. Am J Pathol. 2010; 176(4): 2009-18.
Disclosure of Interest None declared