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THU0297 Serum CXCL8, 10 and 12 are Increased in Patients with Behcet's Disease and CXCL10 Levels are Correlated with Number of Erythematous Nodosum
  1. S.J. Lee1,2,
  2. J.Y. Choi3,
  3. B.Y. Choi4,
  4. D.J. Ko1,
  5. H.M. Kwon1,
  6. J.Y. Moon1,
  7. E.H. Kang5,
  8. J.K. Park1,
  9. E.Y. Lee1,
  10. E.B. Lee1,
  11. Y.W. Song1,2
  1. 1Internal Medicine, Division of Rheumatology, Seoul National University Hospital
  2. 2Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine, Seoul National University
  3. 3Internal Medicine, Seoul National University College of Medicine
  4. 4Internal Medicine, Division of Rheumatology, Seoul Medical Center
  5. 5Internal Medicine, Division of Rheumatology, Seoul National University Bundang Hospital, Seoul, Korea, Republic Of

Abstract

Background Chemokines are multifunctional mediators that control leukocyte recruitment into the inflammatory sites and enhance immune responses. It remains to be investigated which chemokines are important in Behcet's disease (BD).

Objectives The objective of this study was to investigate serum levels of neutrophil and lymphocyte chemoattractants in BD patients and its association with disease activity and symptoms.

Methods We collected sera from patients with BD (n=64) and age-, sex matched healthy controls (n=21). Serum levels of chemokines were assayed for the neutrophil chemoattractants (CXCL1 and CXCL8) and lymphocyte chemoattractants (CXCL9, CXCL10, CXCL12, CXCL13 and CXCL16) by using a multiplex assay. Behcet's disease current activity form (BDCAF) and symptoms were evaluated at the time of blood collection.

Results Serum levels of CXCL8, CXCL10 and CXCL12 were significantly higher in the BD patients than in healthy controls (p<0.001, p=0.050 and p=0.002, respectively). Serum chemokine levels were not associated with BDCAF in BD patients. But CXCL10 levels were significantly higher in patients with erythematous nodosum (EN) than in patients without EN (p=0.008). AdditionaIly, CXCL10 levels were significantly correlated with number of EN (r=0.338, p=0.006). There was no difference of serum level of CXCL1, CXCL9, CXCL13 and CXCL16 between BD and healthy controls

Conclusions Serum levels of CXCL8, CXCL10 and CXCL12 were significantly higher in the BD patients than in healthy controls. CXCL10 levels were correlated with number of EN in BD patients.

Disclosure of Interest None declared

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