Background Eosinophilic granulomatosis with polyangiitis (EGPA) may substantially affects patients' daily life, including their ability to work. However, to date a limited number of studies have investigated the effect of the disease severity on work productivity and non-work activities.
Objectives 1) to describe the productivity outcomes of the Work Productivity and Activity Impairment General Health (WPAI-GH) questionnaire, including absenteeism, presenteeism and activity impairment in patients with EGPA 2) to explore any eventual correlation/association between patients' clinical characteristics and each of these productivity outcomes 3) to investigate any eventual correlation between WPAI-GH outcomes and a battery of questionnaires used to assess self-reported clinical and health outcomes.
Methods Consecutive, unselected patients with EGPA were included in this single center cross-sectional study. A standardized data set including demographic, comorbidities, disease activity score (BVAS), damage score (VDI) and outcome data was collected prospectively. A questionnaire battery incorporating the WPAI-GH was administered along with a number of other questionnaires assessing self-reported clinical and health outcomes including: SF-36, Sino Nasal outcome test-22 (SNOT-22) and Asthma Control questionnaire (ACQ). Statistical analysis: Contingency table, Fisher's exact test, t-test, Mann-Whitney test and Spearman's rank correlation coefficient were employed.
Results Analysis included 26 EGPA patients, with the mean age at onset being 47 years (S.D. 45 years) and disease duration from symptoms onset being 80 months (min 8 mo-max 335 mo). Twenty patients out of 26 were working for pay. Out of them, 10% reported missing work in the past week due to their health problem, accounting for ∼8% of their working time (absenteeism). For patients at work, 15% of their actual work was impaired due to their health problems (presenteeism). In addition, 34% of the patients' regular daily activities (activity impairment) had been prevented due to their health problems. We did not find any relationship between WPAI-GH productivity outcomes and patients' demographic, disease duration, ANCA status or clinical phenotype (EGPA vs HASM). The WPAI absenteeism was moderately correlated with the SF-36 physical component (r=-0.43). The WPAI presenteeism, work productivity loss and activity impairment were moderately correlated with the SNOT-22 (r=0.48 to 0.57). The work productivity loss correlated also with the BVAS score (r=0.44). The WPAI activity impairment was finally moderately correlated with patients' ACQ (r=0.54), VDI (r=0.52) and BVAS (r=0.61) and strongly correlated with both the SF-36 physical (r=-0.65) and mental (r=-0.80) component.
Conclusions Productivity loss was quite common in our series of EGPA patients and should be taken into account by physicians in their treatment considerations.
Disclosure of Interest None declared