Chronic pain is a major debilitating problem and affects approximately 20% of the total adult population and is difficult to treat. Pain is the most important defining clinical presentation of osteoarthritis. Knee OA affects approximately 250 million people world wide. Clinically, there is disparity between the degree of pain perception and the extent of joint damage. This disparity between damage and pain is suggestive for specific mechanisms in the sensory nervous system that drive OA pain. In this presentation we discuss potential peripheral mechanisms leading to chronic pain in the context of OA. In addition, underlying spinal mechanisms with a particular focus on spinal neuroinflammation are discussed.
Disclosure of Interest None declared