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THU0019 Association of HLA-B*41:02 with Henoch-Schönlein Purpura in Spanish Individuals Irrespective of the HLA-DRB1 Status
  1. R. Lόpez-Mejías1,
  2. F. Genre1,
  3. B. Sevilla Pérez2,
  4. S. Castañeda3,
  5. N. Ortego-Centeno2,
  6. J. Llorca4,
  7. B. Ubilla1,
  8. S. Remuzgo-Martínez1,
  9. V. Mijares1,
  10. T. Pina1,
  11. V. Calvo-Río1,
  12. A. Márquez5,
  13. J.A. Miranda-Filloy6,
  14. A. Navas Parejo7,
  15. M. Conde-Jaldόn8,
  16. L. Ortiz-Fernández8,
  17. D. Argila9,
  18. M. Aragües9,
  19. E. Rubio10,
  20. M. Leόn Luque10,
  21. J.M. Blanco-Madrigal11,
  22. E. Galíndez-Aguirregoikoa11,
  23. F. González Escribano8,
  24. J.G. Ocejo-Vinyals12,
  25. J. Martín13,
  26. R. Blanco1,
  27. M. Ά. González-Gay1
  1. 1Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander
  2. 2Medicine Department, Hospital Universitario San Cecilio, Granada
  3. 3Rheumatology Department, Hospital Universitario La Princesa, IIS-Princesa, Madrid
  4. 4Epidemiology and Computational Biology Department, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander
  5. 5Institute of Parasitology and Biomedicine Lόpez-Neyra (IPBLN-CSIC) and Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada
  6. 6Division of Rheumatology, Hospital Universitario Lucus Augusti, Lugo
  7. 7Nephrology Department, Hospital Universitario San Cecilio, Granada
  8. 8Immunology Department, Hospital Universitario Virgen del Rocío, Sevilla
  9. 9Dermatology Department, IIS-IP, Hospital de la Princesa, Madrid
  10. 10Rheumatology Department, Hospital Universitario Virgen del Rocío, Sevilla
  11. 11Rheumatology Department, Hospital Universitario de Basurto, Bilbao
  12. 12Immunology Department, Hospital Universitario Marqués de Valdecilla, Santander
  13. 13Institute of Parasitology and Biomedicine Lόpez-Neyra, CSIC, Granada, Spain

Abstract

Background To determine whether the human leukocyte antigen (HLA) B alleles are implicated in the susceptibility to Henoch-Schönlein purpura (HSP) in the largest series of Caucasian HSP patients ever assessed for genetic studies.

Methods The study population was composed of 349 Spanish patients diagnosed with HSP fulfilling the American College of Rheumatology and the Michel et al. classification criteria, and 335 sex and ethnically matched controls. HLA-B phenotypes were determined by sequencing-based typing (SBT) and analyzed by chi-square or Fisher exact test.

Results A statistically significant increase of HLA-B*41:02 allele in HSP patients when compared with controls was found (8.3% versus 1.5% respectively; p=0.0001; OR (odds ratio) =5.76 [2.15-19.3]). These results remained statistically significant after adjusting for Bonferroni correction (p=0.0028). An internal validation also confirmed the susceptibility effect on HSP associated with HLA-B*41:02 (OR=5.70 [1.98-16.44]). Since a former study described an association between HLA-DRB1*01:03 and HSP susceptibility, we also evaluated the implication of HLA-B*41:02 independently of HLA-DRB1*01:03. Interestingly, the association remained statistically significant (p=0.0004, OR=4.97 [1.8-16.9]). No HLA-B association with specific HSP clinical features was found.

Conclusions Our study indicates that HLA-B*41:02 is associated with the susceptibility to HSP in Spanish patients irrespective of HLA-DRB1 status.

Acknowledgements This study was supported by a grant from “Fondo de Investigaciones Sanitarias” PI12/00193 (Spain). RLM is a recipient of a Sara Borrell postdoctoral fellowship from the Instituto de Salud Carlos III at the Spanish Ministry of Health (Spain) (CD12/00425). FG and BU are supported by funds from the RETICS Program (RIER) (RD12/0009/0013).

Disclosure of Interest None declared

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