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OP0189 High Grade Salivary Gland Involvement, Assessed by Histology or Ultrasonography, Is Associated with a Poor Response to Rituximab in Primary Sjögren's Syndrome Patients
  1. D. Cornec1,2,
  2. S. Jousse-Joulin1,2,
  3. S. Costa3,
  4. T. Marhadour1,
  5. P. Marcorelles3,
  6. J.-M. Berthelot4,
  7. E. Hachulla5,
  8. P.-Y. Hatron5,
  9. V. Goeb6,
  10. O. Vittecoq6,
  11. E. Nowak7,
  12. J.-O. Pers2,
  13. V. Devauchelle-Pensec1,2,
  14. A. Saraux1,2
  1. 1Rhumatologie, CHRU Brest
  2. 2EA2216, INSERM Espri, ERI29, Laboratoire d'Immunothérapies et Pathologies lymphocytaires B, and Labex “IGO”, Université de Brest
  3. 3Anatomie Pathologique, CHRU Brest, Brest
  4. 4Rhumatologie, CHU Nantes, Nantes
  5. 5Service de Médecine Interne, Claude Huriez Hospital, Université Lille Nord-de-France, Lille
  6. 6Rhumatologie, CHRU de Rouen, Bois-Guillaume
  7. 7INSERM CIC 0502, CHRU Brest, Brest, France

Abstract

Objectives To determine whether the extent of salivary gland involvement, assessed using unstimulated whole salivary flow (UWSF), histological focus score or salivary gland ultrasonography (SGUS), is associated with the response to rituximab in patients with primary Sjögren's syndrome (pSS).

Methods 35 pSS patients form the randomized TEARS study, which compared rituximab to placebo, had either centralized salivary gland biopsy or SGUS, at inclusion. Among rituximab-treated patients, 50% were considered responders according to the Sjögren's Syndrome Responder Index (SSRI)-30 definition of the response at week 24.

Results SGUS score was positively correlated to the focus score (r=0.61) and inversely correlated to UWSF (r=-0.68). Conversely, the focus score was not correlated with UWSF. No patients with grade 4 SGUS score responded to rituximab, compared to 88% of patients with SGUS score ≤3. The median focus score at inclusion was 0.3 (0.0-1.3) in the responders versus 4.0 (2.7-5.3) in the non-responders (p=0.02). Conversely, baseline UWSF was not associated with the response.

Conclusions pSS patients with the highest histologic or morphologic salivary gland involvement do not respond to rituximab after 6 months, suggesting that a single 1gX2 rituximab course could be an unsufficient treatment for patients with the highest salivary gland B cell activity.

Disclosure of Interest None declared

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