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AB1114 Prevalence of HLA-B27 in a Cohort of Transplant of a University Hospital in Colombia
  1. C. Villota1,
  2. O. Roa2,
  3. M. Díaz3,
  4. J. Gutiérrez3,
  5. D.G. Fernández-Avila3
  1. 1Internal Medicine, Hospital Universitario San Ignacio - Universidad Javeriana, Bogotá, Colombia
  2. 2Rheumatology, Universidad de Buenos Aires, Buenos Aires, Argentina
  3. 3Rheumatology, Hospital Universitario San Ignacio - Universidad Javeriana, Bogotá, Colombia

Abstract

Background The Human Leukocyte Antigen HLA B 27; is a class I antigen from MHC that is strongly associated with ankylosing spondylitis (AS) and other spondyloarthritis (SPA), with positivities for HLA-B27 in the population from 80 to 95% worldwide. The prevalence of HLA-B27 in the general population varies by geographic area, with ratios ranging between 2-4% in African/African American compared to 8% in Caucasian populations 1

Objectives To determine the proportion of positive HLA B 27 in the population of transplanted and donors treated at the San Ignacio University Hospital; their clinical characteristics and relationship to the presence of spondyloarthritis.

Methods It was performed a descriptive cross-sectional study of 465 individuals typed for HLA of a cohort of transplants in a university hospital in Colombia including donors and receivers. Designing a database in Excel to include data relevant to the study. The search was performed in hospital records and telephone contact for family not treated at the hospital to extract information.

Results 465 individuals with an age range between 10 and 80 years with a mean of 44.9 years (SD: 14.04); finding 21 positive cases for HLA B 27 indicating a prevalence of 4.5% positivity for HLA-B27 in this population. At evaluating the behavior by gender, a proportion of HLA B 27 of 6,5% was found in the group of men (n=261; 56.1%) compared with 2.0% in women. Of the 21 patients positive for HLA B 27 it was found that 4 of them (19%) had joint pain of small and large joints so they were referred to evaluation by the Rheumatology service at Hospital where the presence of spondyloarthritis or other autoinmune disease was discarted.

Proportion of HLA B 27 (+) in the population of renal and bone marrow transplanted and donors at San Ignacio Universitary Hospital

Conclusions It has been described in the literature the prevalence of HLA B 27 in ranges from 2% to 8%, according to the region evaluated; it was found in our study a ratio of 4.5% of the total population and comparing by gender a higher proportion in males (6.5% compared with 2% in women). Spondylitis or other autoimmune disease were not detected in any patient of the series evaluated in our study; although 19% of the populatinon with positive HLA B 27 was referred to rheumatology for articular symptoms discarding the presence of it. San Ignacio Universitary Hospital is a reference center of the city to perform transplants, so it is important to emphasize the prevalence found in our study that fits within international parameters reported.

Disclosure of Interest None declared

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