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AB1015 Sexual Maturation in Brazilian Girls with Juvenile Idiopathic
  1. S.H. Machado1,
  2. P.J.C. Marostica2,
  3. L.M. Goncalves3,
  4. P. Lora4,
  5. L. Trindade5,
  6. R.M. Xavier1
  1. 1Rheumatology
  2. 2Pediatrics, Hospital de clinicas de Porto Alegre
  3. 3Pontificia Universidade Catόlica do Rio Grande do Sul, Porto Alegre
  4. 4Imunology
  5. 5Universidade Vale do Rio dos Sinos, São Leopoldo, Brazil

Abstract

Background Juvenile Idiopathic Arthritis (JIA) is among the most prevalent rheumatic disease in children. Abnormal puberty is often reported in chronic inflammatory diseases such as JIA.Such condition may be secondary to inflammation, undernutrition or medications (pex: glucocorticoids)

Objectives The aim of this study was to compare sexual maturation of girls with JIA and age-gender paired healthy control group from Southern Brazil.

Methods A case-control study was conducted with all consecutive JIA female patients followed at Rheumatology outpatient clinics from Clinics Hospital of Porto Alegre and health control (HC) subjects aged six to 18 year.JIA diagnosis was made according to the criteria of the International League of Association for Rheumatology. Demographic and disease related data were obtained as well as: Tanner breast stage (Bre), menarche age and ultrasound measurements of uterine volume (UV), pulsatility index by Color Doppler (PI) and Endometrial thickness (ET). Parametric tests (chi-square and t-test) were used to compare patients and healthy controls. A lower than 0.05 p value was considered statistically significant.

Results Forty-two JIA girls and 42 HC were included in a cross-sectional study. The JIA girls mean of age was 12.0 (3.08) and HC was 12.0 (3.16) years. Ten percent had JIA systemic type, 31% oligopersistent, 59,6% oligoextended and polyarticular course. The mean age of JIA patients in stage tanner II was significantly higher than HC (11,2 [1,1) vs 9,6 [0,9]). All HC (10) girls above 15 years-old were in a stage tanner V in contrast to JIA patients that only fifty percent (5) was at this stage at this age. There was no difference in menarch age, weight and height between HC and JIA in all stages of tanner. In relation to ultrasound findings, there was only a difference in the PI on stage tanner II.

Conclusions These results showed that JIA patients began and finished puberty maturation latter than HC individuals. However, these are preliminary data and more subjects have been enrolled in the study. Further investigation about the relation between delayed puberty and inflammation are still needed to better clarify this topic and to challenge new therapeutic strategies.

References

  1. Asăvoaie C, Fufezan O, Coşarcă M. Ovarian and uterine ultrasonography in pediatric patients. Pictorial essay. Med Ultrason. 2014 Jun;16(2):160-7.

  2. Brämswig J1, Dübbers A. Disorders of pubertal development. Dtsch Arztebl Int. 2009 Apr;106(17):295-303;

  3. El Badri D, Rostom S, Bouaddi I, et al. Sexual maturation in Moroccan patients with juvenile idiopathic arthritis. Rheumatol Int. 2014 May;34(5):665-8

  4. Maher SE, Ali FI. Sexual maturation in Egyptian boys and girls with juvenile rheumatoid arthritis. Rheumatol Int. 2013 Aug;33(8):2123-6.

Disclosure of Interest None declared

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