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AB1007 Determination of Free Carnitine and Acyl-Carnitine Status of Patients with Juvenile Idiopathic Arthritis
  1. E. Kıykım1,
  2. A.-C. Aktuglu-Zeybek1,
  3. K. Barut2,
  4. T. Zubarioglu1,
  5. M.S. Cansever1,
  6. A. Aydin3,
  7. O. Kasapcopur2
  1. 1Metabolic Diseases, Istanbul University, Cerrahpasa Medical Faculty, Department of Pediatric Metabolic Diseases
  2. 2Pediatric Rheumatology, Istanbul University, Cerrahpasa Medical Faculty, Department of Pediatric Rheumatology
  3. 3Pediatric Rheumatology, Istanbul University, Cerrahpasa Medical Faculty, Department of Pediatric Metabolic Diseases, Istanbul, Turkey

Abstract

Background Juvenile idiopathic arthritis (JIA) is not a single disease; it's group of all arthritis with unknown etiology, starting before 16 years of age and lasting at least 6 weeks long. JIA is the most common rheumatic disease in childhood. Carnitine is an important molecule in cellular energy metabolism. Secondary carnitine deficiency can be detected in chronic diseases by either renal loss or increased demand.

Objectives We hypothesized that secondary carnitine deficiency may be seen to increased demand in JIA patients. In the present study our aim is to determine free carnitine and acyl-carnitine levels of Turkish JIA patients.

Methods 114 patients with a diagnosis of juvenile idiopathic arthritis and a healthy 50 individuals served as control group, were included to the study. A fasting blood sample was taken for free carnitine and acyl-carnitine esters with tandem mass spectrometry from children in both groups.

Results Screening of acyl-carnitine profile revealed free carnitine, C14, C16, C16-OH, C18 and C18:2-OH carnitine levels were higher (p<0,0001, p<0,0001, p<0,0001, p<0,0001 and p=0,004 respectively), while C6 carnitine levels were lower (p<0,0001) in JIA patients than the control group. Free carnitine levels were significantly higher (48.05±13.36 μmol/L) in patients under anti-inflammatory drug therapy than those who did not receive any treatment (43.18±7.96 μmol/L) (p=0,004).

Conclusions In the present study we were not able to define secondary carnitine deficiency in JIA patients, therefore routine carnitine supplementation is not recommended in all patients with JIA.

References

  1. Ravelli A, Martini A. Juvenile idiopathic arthritis. Lancet. 2007 Mar 3; 369(9563):767-78.

  2. Stanley CA. Carnitine deficiency disorders in children. Ann N Y Acad. Sci.2004; 1033:42–51.

Disclosure of Interest None declared

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