Background Familial Mediterranean fever (FMF) is the most common auto inflammatory syndrome with recurrent inflammatory attacks of fever and serositis lasting 1-4 days. It may have ongoing subclinical inflammation during attack-free periods. Blood neutrophil to lymphocyte (N/L) ratio has been used as a simple marker of inflammation both in cardiac and non-cardiac disorders.
Objectives In this study, we aimed to investigate the relationship between neutrophil to lymphocyte ratio and FMF.
Methods There were 160 participants (68.4%) in the FMF patient group, and 74 participants (31.6%) in the control group. Ninety of patients (38.5%) were in attack-free period, and 70 (29.9%) were in attack period. Neutrophils and lymphocyte counts were recorded and N/L ratio was calculated.
Results General group comparisons revealed a statistically significant difference between groups (p<0.001), and post-hoc pairwise comparisons showed that the highest values of neutrophil/lymphocyte rates were found in the patients at attack period. Patients in attack-free period and the participants in control group had similar levels of neutrophil/lymphocyte ratios (p=0.457), and they had lower ratios than the patients did at attack period (p<0.001 for both) (Table 1).
Conclusions In this study our results shows that N/L ratio is higher in patients at attack period compared with FMF patients at attack free period and control groups. N/L ratio may indicate FMF attack period. Since there was no significant difference between attack free patients and control groups, N/L ratio cannot be used as a subclinical inflammation marker.
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Disclosure of Interest None declared