Article Text

AB1005 Associations of Neutrophil/Lymphocyte Ratio in Attack Period and Attack-Free Period in Pediatric FMF Patients
  1. O. Basaran,
  2. B. Acar Celikel,
  3. N. Uncu,
  4. N. Cakar
  1. Ankara Child Health Hematology, Oncology Education and Research Hospital Pediatric Rheumatology, Ankara, Turkey


Background Familial Mediterranean fever (FMF) is the most common auto inflammatory syndrome with recurrent inflammatory attacks of fever and serositis lasting 1-4 days. It may have ongoing subclinical inflammation during attack-free periods. Blood neutrophil to lymphocyte (N/L) ratio has been used as a simple marker of inflammation both in cardiac and non-cardiac disorders.

Objectives In this study, we aimed to investigate the relationship between neutrophil to lymphocyte ratio and FMF.

Methods There were 160 participants (68.4%) in the FMF patient group, and 74 participants (31.6%) in the control group. Ninety of patients (38.5%) were in attack-free period, and 70 (29.9%) were in attack period. Neutrophils and lymphocyte counts were recorded and N/L ratio was calculated.

Results General group comparisons revealed a statistically significant difference between groups (p<0.001), and post-hoc pairwise comparisons showed that the highest values of neutrophil/lymphocyte rates were found in the patients at attack period. Patients in attack-free period and the participants in control group had similar levels of neutrophil/lymphocyte ratios (p=0.457), and they had lower ratios than the patients did at attack period (p<0.001 for both) (Table 1).

Table 1.

Neutrophil/lymphocyte ratios in study groups

Conclusions In this study our results shows that N/L ratio is higher in patients at attack period compared with FMF patients at attack free period and control groups. N/L ratio may indicate FMF attack period. Since there was no significant difference between attack free patients and control groups, N/L ratio cannot be used as a subclinical inflammation marker.


  1. Uluca Ü, Ece A, Şen V, Karabel D, Yel S, Güneş A, Tan I, Sabas M. Usefulness of mean platelet volume and neutrophil-to-lymphocyte ratio for evaluation of children with Familial Mediterranean fever. Med Sci Monit. 2014 Sep 5;20:1578-82.

  2. Celikbilek M, Dogan S, Akyol L, Borekci E, Zararsiz G, Kozan M, Gunaydin I. Neutrophil-Lymphocyte Ratio in Patients With Familial Mediterranean Fever. J Clin Lab Anal. 2014 Mar 28.

  3. Ahsen A, Ulu MS, Yuksel S, Demir K, Uysal M, Erdogan M, Acarturk G. As a new inflammatory marker for familial Mediterranean fever: neutrophil-to-lymphocyte ratio. Inflammation. 2013 Dec;36(6):1357-62.

Disclosure of Interest None declared

Statistics from

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.