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AB0988 Validation of the Systemic Lupus International Collaborating Clinics (SLICC) Classification Criteria in Juvenile Systemic Lupus Erythematosus
  1. K.J.N. Kimseng,
  2. L.F. Dans,
  3. C.A. Tee
  1. Pediatric Rheumatology, Philippine General Hospital, Manila, Philippines

Abstract

Background The current use of the SLICC classification criteria for juvenile systemic lupus erythematosus (jSLE) is extrapolated from an adult-validated study.1 Efforts have been conducted to validate its applicability in the pediatric population.2,3

Objectives To validate the SLICC classification criteria among juvenile SLE patients

Methods A diagnostic criteria validity study was conducted. Medical records of <19 years old patients, who were seen in a tertiary hospital from June 2012 to June 2014, were reviewed to make 300 case summaries. Included were 150 jSLE and 150 non-jSLE cases. Non-jSLE cases, with jSLE as a consideration, comprised the control group. Patients who had no definite diagnosis, or who were lost to follow-up, were excluded. Each case summary was evaluated by at least 3 of 7 pediatric rheumatologists by utilizing the SLICC criteria. A consensus diagnosis for each case was reached based on majority agreement (>50%) of the individual subspecialist assessments. The clinical diagnosis of the team of attending physicians, with at least 1 pediatric rheumatologist, was used as the gold standard. The sensitivity, specificity and number of misclassified cases were determined.

Results The sensitivity of the SLICC criteria is at 94.0% (95%CI 88.9-97.2), and specificity at 96.7% (95%CI 92.4-98.9) in the cohort of Filipino jSLE patients. One-forty-one cases were correctly classified as jSLE, while 145 controls were correctly classified as non-jSLE. There were 9 false negatives, while 5 controls were false positives.

Conclusions The SLICC classification criteria is a valid guide for clinical practitioners to diagnose patients afflicted with jSLE.

References

  1. Petri, M et al. Arthritis & Rheumatism 2012; 64: 2677-2686.

  2. Fonesca, AR et al. Rheumatology. 2014. doi:10.1093/rheumatology/keu278.

  3. Sag, E at al. Clinical and Experimental Rheumatology. 2014 June; 32 (3): 440-444.

Acknowledgements Dr. Pauline Camposano, Dr. Carien-Gulay-Carvajal, Dr. Christine Bernal, Dr. Karen Cruz, Dr. Shanida Camomot, and Dr. Maria Kristine Belen-Ciabal

Disclosure of Interest None declared

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