Article Text

PDF
AB0912 Subclinical Hypovitaminosis D and Osteoporosis in Breast Cancer Patients
  1. T.A. Gheita1,
  2. S. Sayed1,
  3. W. Hammam2,
  4. G. Hegazy3
  1. 1Rheumatology, Rheumatology and Clinical immunology Department, Faculty of Medicine, Cairo University
  2. 2Oncology, Faculty of Medicine, Cairo University, Cairo, Egypt
  3. 3Clinical Biochemistry, Faculty of Medicine, King Abdulaziz University, Riyadh, Saudi Arabia

Abstract

Background Vitamin D may play a role in breast cancer prevention. While the association between Vitamin D and breast cancer risk/prognosis is still controversial, a high proportion of women at-risk for breast cancer or affected by the disease have deficient vitamin D levels.

Objectives This study was designed to detect the incidence of osteoporosis and circulating concentration of 25-hydroxy vitamin D level in breast cancer patients as well as their relation to the treatment received and to stage of breast cancer.

Methods Seventy-four female patients with breast cancer were included in the study; their mean age was 47.89±9.59years. Another fifty-two age and sex matched subjects were included as control. All patients were receiving chemotherapy, 40 received hormonal therapy, 50 radiotherapy and 10 surgically removed. Vitamin D level and dual energy x-ray absorptiometry (DXA) were performed for patients and control

Results Vitamin D level was significantly higher in the control (23.66±5.2 IU/L) than in patients (18.37±6.25 IU/L) (p<0.0001). There was a tendency to a normal DXA score in the forearm of the patients while the score of the hip and spine were significantly different from that of the control (p=0.001 and p=0.034 respectively). In patients, there were significant correlations between 25(OH)D3 and hip DXA (r=0.25, p=0.03), and significant negative correlations between tumor grades and DXA of hip, forearm and spine (r= -0.42, r=-0.39, r=-0.45 respectively; p<0.0001).

Conclusions Our finding support low serum vitamin D concentration in breast cancer patients. In addition, their BMD of the hip is obviously reduced. The sub-clinically detected hypovitaminosis D and osteoporosis throw light on the importance of offering calcium and vitamin D supplements to breast cancer patients. It is further recommended that breast cancer patients have a DXA scan performed at baseline and repeatedly on a yearly basis.

Disclosure of Interest None declared

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.