Background The data concerning the association between metabolic syndrome (MS) and the bone is limited and conflicting
Objectives The aim of our study was to evaluate the difference in bone mineral density in postmenopausal women with and without MS, and identify the components of this syndrome affecting most the bone mineral density.
Methods This is a cross-sectional study conducted in the department of rheumatology of Hassan II University Hospital, Fez, Morocco. All patients benefited from Bone densitometry measured by DXA. A lipid levels, carbohydrate, calcium phosphate, and the dosage of 25 (OHvit D2 and D3) were measured. Metabolic syndrome was assessed according to the National Cholesterol Education Program Adult Treatment Panel III criteria. Statistical analysis was done using using SPSS v18 softwar. A univariate regression analysis and a logistic regression was used to identify the metabolic syndrome factors influencing bone mineral density.
Results 170 postmenopausal patients were included, 81 with and 89 without syndorme metaboloc. The mean age of patients was 59±6.5 years. The mean age of menopause was 49±6.4 years. The mean BMI was 29.7 kg/cm2 ±4.1. The vitamin D deficiency was found in 62.7% with a mean of 18.6±8.8 ng/ml. Seventy patients were osteoporotic and osteopenic were seventy-two. The prevalence of metabolic syndrome was 48.5%. The two groups of patients with and without metabolic syndrome differed on the mean age (p=0.05), body mass index (p=0.002), HDL (p<0.001), glucose (p<0.001), triglycerides (p<0.001) and waist (p<0.001)
In univariate analysis, no association was found between the presence of metabolic syndrome and lumbar bone mineral density (p=0.36) and at the hip (p=0.29)
Conclusions This study suggests that metabolic syndrome does not affect the bone mineral density.
Disclosure of Interest None declared