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AB0886 Comparative Characteristics of the Change in Bone Mineral Density in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis
  1. A. Vasilyev1,
  2. D. Abdulganieva2,
  3. S. Lapshina2,
  4. L. Myasoutova2
  1. 1Clinical Hospital 7
  2. 2Kazan State Medical University, Kazan, Russian Federation


Objectives To determine and compare the pattern of change in bone mineral density (BMD) in patients with rheumatoid arthritis (RA) and ankylosing spondylitis (AS).

Methods The study involved 52 patients with definite diagnosis of RA (1987 criteria.): women - 28 (53.8%), men - 24 (46.2%), aged 25 to 67 years (mean age 42,5±11, 3), with duration of disease - 8,2±6,7 years. Also, 58 patients were examined with documented diagnosis of AS according to ASAS (men - 33 (56.9%), women - 25 (43.1%), mean age 44,1±8,2 years, mean disease duration - 6 9±3,9 years. no significant differences by sex and age in these groups have been identified.

Results According to the world criteria when evaluating BMD in the lumbar spine in patients with RA normal BMD was observed in 8 (15.4%) patients, osteopenia - in 29 (55.8%) and OP - in 15 (28.8%) people. In the femoral neck BMD was observed normal in 15 (28.8%) patients with rheumatoid arthritis, osteopenia - in 24 (46.2%) and OP - 13 (25.0%) patients. Among AS patients normal BMD was observed in 10 (17.2%) patients, osteopenia - in 33 (56.9%) and OP - in 15 (25.8%) patients. In the proximal femur BMD normal occurred in 12 (20.7%) patients with rheumatoid arthritis, osteopenia - in 32 (55.2%) and OP - in 14 (24.1%) patients. When comparing BMD at 3 points was found that patients with RA BMD was significantly lower (p<0,01) at the femoral neck (0,87±0,18) and distal forearm (0,81±0,32), than AS patients (BMD at the femoral neck 0,90±0,18; in the distal forearm 0,85±0,29). For lumbar spine BMD similar differences in the two groups were established, but they were not significant. In assessing the functional status was found that patients with RA high index HAQ, the number of tender and swollen joints was significantly (p<0,05) correlated with a more pronounced decrease in BMD in the spine and femoral neck. In AS similar correlation was observed in the spine, but was not significant.

Conclusions In this study, it was shown that decreasing BMD observed in a significant number of patients with RA and AS. In RA, decrease in spine BMD was significantly correlated with reduced functional status and increased number of tender and swollen joints. In AS this relationship was not significant.

Disclosure of Interest None declared

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