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AB0854 The Prevalence of Secondary Osteoarthritis of the Knee in Patients with Rheumatoid Arthritis
  1. I. Starodubtseva,
  2. L. Vasilieva,
  3. A. Nikitin,
  4. N. Barsukova
  1. Internal Diseases, Nn Burdenko Voronezh State Medical Academy, Voronezh, Russian Federation

Abstract

Background Among the complications in patients with RA often can be found secondary osteoarthritis, atherosclerosis, systemic osteoporosis1,2.

Objectives The aim of the study was to estimate the prevalence of secondary osteoarthritis of the knee in patients with rheumatoid arthritis and to reveal it association with the parameters of basic disease.

Methods 565 RA patient's histories (diagnosis according to the criteria of ACR/EULAR) from the rheumatology in-patient clinic with the mean age 48.4±10, 85.4% female and duration of the disease 3-15 years were reviewed. The features of secondary OA of the knee in patients with RA were assessed with the use of questioning (clinical symptoms, anamnesis of the disease), examination (ultrasonography (US) and X-ray of the joints).

Results We revealed secondary OA of the knee in 71% of patients with RA. Secondary OA was diagnosed predominantly in anti-CCP pos. patients (68,6%), with DAS 28>5,3 (in present and in the anamnesis) and with the duration of the disease 7-15 years. The more statistical significant associations were observed between DAS 28 and US, X-ray (corr. r=0,734, p<0,01), the duration of the disease and US and X-ray (r=0,671, p<0,05), US, X-ray and morning stiffness (r=0,526, p<0,05).

Conclusions These findings demonstrate the high prevalence of secondary osteoarthritis of the knee in patients with rheumatoid arthritis. This comorbid medical condition associates with the increase of activity, morning stiffness and duration of underlying disease (RA).

References

  1. Peat G, et al. Clinical classification criteria for knee osteoarthritis; performance in the general population and primary care. Ann Rheum Dis 2006;65:1363–1367.

  2. Michaud K, Wolfe F. Comorbidities in rheumatoid arthritis. Best Practice & Res Clin Rheumatol 2007;21:885–906.

Disclosure of Interest None declared

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