Article Text

PDF
AB0804 Increased Carotid Intima-Media Thickness in Psoriatic Arthritis Patients Compared with Systemic Lupus Erythematosus Patients and Healthy Controls
  1. A. Dünya1,
  2. H. Yarkan2,
  3. P. Cetin2,
  4. G. Can2,
  5. N. Akkoc2,
  6. F. Onen2
  1. 1Internal Medicine
  2. 2Rheumatology, Dokuz Eylül University Faculty of Medicine, Izmir, Turkey

Abstract

Background Patients with psoriatic arthritis (PsA) and systemic lupus erythematosus (SLE) are at increased risk of atherosclerosis. An increased carotid intima-media thickness (IMT) is considered to be a marker of early atherosclerosis.

Objectives The aim of this study was to investigate carotid IMT in patients with PsA and compare it with those in patients with SLE and healthy controls.

Methods Non-diabetic patients with PsA and age and body mass index (BMI) matched, non-diabetic patients with SLE, and healthy controls were included in this study. Bilateral carotid IMTs were evaluated by using B-mode ultrasonography in PsA patients and compared with those in SLE patients and healthy controls.

Results There were 42 PsA patients (30 female, 12 male; mean age: 45.36±8.9 years) who fulfilled CASPAR criteria and 38 patients (37 female, 1 male; 41.2±13.0 years) who fulfilled the 1982 revised American College of Rheumatology (ACR) criteria for SLE. Thirthy healthy hospital workers (27 female, 3 male; mean age 41.2±6.8 years) were recruited as healthy controls.

The frequency of hiperlipidemia was found to be significantly higher in patients with PsA than SLE patients and healthy controls (p<0.001) but hypertension was more common in SLE patients (p=0.002). While serum CRP levels were higher in PsA patients than control patients and healthy controls, SLE patients had higher ESR levels than the both control groups (p<0.001).

The mean carotid IMT was found to be higher in PsA patients (0.76mm ±0.15) in comparison with the SLE patients (0.58±0.11) and healthy control group (0.57±0.12) (p<0.001).

Table 1.

B-mode ultrasonography results in the study subjects

Conclusions This study shows that carotid IMT measurements are higher in PsA patients than SLE patients and healthy controls. A higher hyperlipidemia frequency and male predominancy in PsA patients may be partly responsible for the increased carotid IMT compared with SLE patients.

Disclosure of Interest None declared

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.