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AB0777 Work Productivity Associated with Disease Activity and Functional Ability in Italian Patients with Axial Spondyloarthritis: Results for Space-Cohort
  1. M. Lorenzin,
  2. M. de Hooge,
  3. P. Frallonardo,
  4. A. Ortolan,
  5. L. Punzi,
  6. R. Ramonda
  1. University of Padova, Department of Medicine, Division of Rheumatology, Padova, Italy

Abstract

Background Several studies show that work productivity is related to disease activity and functional ability in patients with axial spondyloarthritis (axSpA). Also socioeconomic status of patients can have an impact on the work productivity. However, these are studies in patients with sustained axSpA.

Objectives Investigate work productivity and wheter there is a correlation with disease activity in Italian patients with early axSpA.

Methods Baseline data was used of patients with BP (≥3 months, ≤2 years, onset <45 years) of unknown origin included by the Italian center of the SPACE cohort. Patients were diagnosed by the treating rheumatologist. Work productivity was measured by the Work Productivity and Activity Impairment (WPAI) questionnaire. Absenteeism (work absence due to illness), presenteeism (reduced productivity while at work) and work productivity loss (WPL, combining absenteeism and presenteeism) over past week were reported. Disease activity was assessed by the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI; low (<4) and high (≥4) disease activity) and Ankylosing Spondylitis disease activity score (ASDAS; inactive disease (<1.3), moderate disease (1.3-2.1), high disease (2.1-3.5) and very high disease activity (>3.5)). Functional ability was assessed by Bath Ankylosing Spondylitis Functional Index (BASFI; high (<2.5) and low (≥2.5) functional ability).

Results Out of 51 patients 21 are male (41.2%), average age at onset back pain is 29.7 (±8.7) years, average duration of back pain is 12.9 (±8.7) months, 16 (31.4%) are HLA-B27+ and 48 (94.1%) have IBP. Average scores for BASDAI (4.5±2.6), ASDAS (2.3±1.0) and BASFI (1.7±2.1) are found. There are 16 patients doing only unpaid activities and 35 patients have paid jobs, of which 6 patients combine this with unpaid activities. On average patients work 36.4 hours/week, absenteeism is 8.3%, presenteeism 28.6% and WPL 33.7%. Presenteeism is statistically significant different between patients with paid (32.6%) and unpaid (18.6%) work. Absenteeism (paid; 7.9% and unpaid; 8.3%) and WPL (paid; 36.6% and unpaid; 25.6%) are not. A decrease in work productivity is seen with an increase in disease activity and functional ability. Correlations are found between disease activity (ASDAS/BASDAI) and absenteeism (β=6.08**/2.65**), presenteeism (β=16.04**/5.80**) and work productivity loss (β=18.86***/7.12***). Also functional ability and absenteeism (β=4.32***), presenteeism (β=4.62*) and work productivity loss (β=7.31***) are correlated. *p<0.05**p<0.01***p<0.00

Conclusions Work productivity impairment is related to disease activity and functional ability in Italian patients with early onset of axSpA.

Disclosure of Interest None declared

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