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AB0668 A Pilot Study of the Eicosapentaenoic Acid/Arachidonic Acid (EPA/AA) Ratio Level of Japanese Patients with Behçet's Disease
  1. T. Kobashigawa,
  2. Y. Nanke,
  3. H. Yamanaka,
  4. S. Kotake
  1. Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan


Background Kürkçüoğlu (1) reported for the first time for the efficacy of eicosapentaenoic acid (EPA) to the patients of Behçet's disease (BD). In Japan, the anti-inflammatory efficacy of EPA to the patients with BD was reported (2, 3). Recently, low level of EPA/AA ratio protecting the events of coronary artery disease was reported in Japan (4, 5). The level of EPA/AA ratio in the patients with BD was not elucidated in the daily clinical practice.

Objectives To investigated the relationships between states of BD and the level of EPA/AA ratio of the patients with BD in daily medical practice.

Methods We analyzed the levels of EPA/AA ratio in 25 patients with BD. The examinations of fatty acid fractions were performed in a daily general blood survey. We keep the regulation of medical insurance for the whole nation. The disease activity was shown with the score of patient's global assessment VAS (PtGA), in this study. Our hypothesis was that the level of EPA/AA ratio is decreased in the vascular-BD patients as for an anti-inflammation and anti-vasculitis.

Results We analyzed 25 patients with BD who visited our clinic in resent 2 years from 2012 to 2013. The characteristics of 25 patients with BD were as shown below: oral lesions were shown in all 25 patients with BD, skin lesions in 24, genital ulcers in 19, ocular lesions in 10, arthritis in 19, intestinal lesions in 11, neural lesions in 3 and vascular lesions in 5. The total 3 times were analyzed in this study, thus the characteristics of our total patients were below: oral lesion 75, skin lesions 71, genital ulcer 61, ocular lesions 26, arthritis 59, intestinal lesions 40, neural lesions 9 and vascular 19, and the average of EPA/AA ratio was 0.41 (SD =0.30). We participated this 75 into 3 categories: 19 were over the normal EPA/AA ratio (0.11 – 0.5), 54 were within the normal ratio and 2 were under the normal ratio. Also the mean EPA/AA ratio (SD) were 0.84 (0.29), 0.27 (0.097) and 0.077 (0.0011), respectively. Our hypostasis was confirmed, and the 2 patients of under the standard value of EPA/AA/ratio were same one patients who was an intestinal-BD patient and had sever digestive symptoms at the time. The decrease in-take was the cause of the decreasing EPA/AA ratio.

Conclusions The level of EPA/AA ratio was not related the activities in the Japanese vascular-BD patients.


  1. Kürkçüoğlu, N. and Tandoğdu, R: Brit J Dermatol. 121: 667-8, 1989.

  2. Annual report of the Behçet's Disease Research Committee of Japan. 185-7, 1992.

  3. Annual report of the Behçet's Disease Research Committee of Japan. 160-2, 1993.

  4. Yokoyama M, et al. Lancet 2007: 369. 1090-8.

  5. Ninomiya T, et al. Atherosclerosis. 2013; 231. 261-7.

Disclosure of Interest None declared

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