Article Text

AB0659 Characteristics of Neurological Manifestations of Behçet's Disease: About 60 CASES
  1. N. Boughanmi,
  2. S. Boughanmi,
  3. A. Choker,
  4. N. Miladi
  1. National Institute of Neurology, Tunis, Tunisia


Background Behçet's disease (BD) is a chronic multisystem inflammatory disorder wich can involve the central nervous system. Neurological involvement is one of the most devastating manifestations of BD.

Objectives The purpose of this study was to describe epidemiological and clinical characteristics of neurological involvement in BD.

Methods The medical notes of 60 patients with neuro-behçet's disease (NBD) fulfilling the criteria of the international study group for BD were retrospectively reviewed.

Results Sixty patients with NBD were studied. Their mean age was 31,8 years; 50 were men and 10 were women. Average disease duration of BD before neurological manifestations onset was 5,1 years. Parenchymal involvement occurred in 34 patients (56,66%) [brainstem: 13 (38,23%), hemispheric involvement: 10 (29,41%), aseptic meningitis: 8 (23,52%), spinal cord: 3 (8,82%)]. Non-parenchymal NBD occurred in 26 patients (43,33%). Involvement of the main vascular structures was the most common non-parenchymal NBD found in 20 patients (76,92%) consisting of cerebral vein thrombosis (CVT) in 16 cases and cerebral arterial thrombosis in 4 cases. The mean duration of follow up of patients with NBD was 5 years.Complete recovery or improvement with mild neurological impairement was seen in 34 cases,improvement with severe disability in 12 cases,worsening in 7 cases,the course was stationary in 4 cases and 3 patients died.

Conclusions Clinical and epidemiological features of NBD are various.In our cohort, NBD occurred frequently in men and was more serious especially in parenchymal involvement.


  1. Al-Araji A, Kidd DP. Neuro-Behçet's disease: epidemiology, clinical characteristics, and management. Lancet Neurol. 2009;8(2):192-204.

Disclosure of Interest None declared

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