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AB0655 Cross-Cultural Adaptation and Validation of The Behçet's Syndrome Activity Score (BSAS) to Brazilian Portuguese Language: Strong Correlation with Brazilian Behçet's Disease Current Activity form (BR-BDCAF)
  1. O.G. Colman,
  2. L.L. Prado,
  3. C.G.S. Saad,
  4. M. Levy-Neto,
  5. C.R. Gonçalves
  1. Rheumatology Division, Faculdade De Medicina Da Universidade De Sao Paulo, São Paulo, Brazil


Background Assessment of Behçet's Syndrome (BS) activity has been a concern since a treat-to-target strategy may improve disease outcome. The Brazilian Behçet's Disease Current Activity Form (BR-BDCAF) is currently validated for Brazilian Portuguese, however, it is completed by the physician. Developed originally in English, the Behçet's Syndrome Activity Score (BSAS) is the first patient-reported assessment tool, which would be useful in clinical routine use and clinical trial evaluations.

Objectives To perform a cross-cultural adaptation of the BSAS to Brazilian Portuguese language and to evaluate its reliability in a population of Brazilian patients with BS, comparing to BR-BDCAF as a gold standard pattern.

Methods Brazilian Portuguese version of the BSAS, named BR-BSAS, was obtained according to established guidelines. Fifty-five BS patients, diagnosed according to the International Study Group for Behçet's Disease criteria, were requested to complete the BR-BSAS. A rheumatologist performed the BR-BDCAF on the same visit. Fifteen patients were selected for a second visit two weeks later, and completed the BR-BSAS once again. Descriptive statistics, intraclass correlation coefficient, internal consistency were calculated to assess reliability and validity of BR-BSAS. Also, we used Pearson coefficient to analyze correlation between the two questionnaires (BR-BSAS and BR-BDCAF).

Results In this study group, 65.3% were females, with a mean age of 45.6 (SD 13.0) years and a mean disease duration of 15.9 (SD 13.0) years. The test-retest reliability of BSAS presented a good level (ICC=0.839, 95% CI [0.596-0.943]). Internal consistency was also acceptable, with a Cronbach's alpha of 0.773. Mean BR-BSAS score (range 0-100) was 31,29 (SD 24,54) and mean BR-BDCAF score (range 0-12) was 3,41 (SD 2,34). A strong correlation between BR-BSAS and BR-BDCAF scores was found (r=0.750).

Conclusions BR-BSAS may be used to assess disease activity in Brazilian BS patients, with a strong correlation between BR-BSAS and BR-BDCAF scores. As a self-reported measure, BR-BSAS may easier to use in clinical practice, adding a patient-derived outcome that may help to improve therapy management decision.

Disclosure of Interest None declared

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