Article Text

PDF
AB0653 Sarcoïdosis: Osteoarticular Involvement – 57 Cases
  1. K. Echchilali1,
  2. M. Benzakour2,
  3. F.-Z. Alaoui2,
  4. F. Arif2,
  5. M. Moudatir2,
  6. H. Elkabli2
  1. 1Internal Medicine
  2. 2University Hospital, Casablanca, Morocco

Abstract

Background Sarcoïdosis is a multisystem granulomatous disease in which multiple organs, including the locomotor system, may be involved. Osteoarticular manifestations of sarcoidosis may be specific or nonspecific. They may be the presenting feature or may occur late after onset, either isolated or combined with other clinical manifestations.

Objectives The aim of this study was to describe the clinical and therapeutic features of the osteoarticular sarcoidosis in Moroccan patients

Methods It was a monocentric study realized in internal medicine department over 30 years (January 1985- August 2014) and including 57 sarcoid patients with osteoarticular manifestations. The diagnosis was based on a set of arguments (clinical, biological and radiological) with at least one positive biopsy site

Results 57 patients among 111 cases of sarcoïdosis had osteoarticular manifestations (prevalence: 53,35%). The female sex was predominant (52 women/5 men) with a mean age of 44 years (range: 25-49). Osteoaticular involvement revealed the disease in 8,1% of cases. Joint damage was the most frequent (91,22%) and was made inflammatory arthralgia (50,87%), Löfgren's syndrome (7,01%), chronic polyarthritis (31,57%) and acute oligoarthritis (8,77%). Bone involvement revealed sarcoidosis in 2 cases and was noted in 15,78% of patients. 8 patients (14,03%) had dactylis with cystic lesions, osteitis, periosteitis or destructrice lesions. The jaw hypertrophy was noted in 1 case. Bone biopsy had revealed the sarcoidosis granuloma in 4 cases where it was performed. One of our patients had a clinical miopathy and two others combined an ankylosing spondyloarthritis. Treatment was based on the non -steroidal anti-inflammatory drugs, associated or not to hydroxychloroquine or methotrexate. Glucocorticoïds were prescribed in the bone involvement. The evolution was good in the most of our patients.

Conclusions Sarcoïdosis is a granulomatous systemic disease potentially involving the locomotor system. It is characterized by arthralgia, oligoarthritis and polyarthritis. Osseous involvement is rare and primarily affects small and distal bones. Corticosteroids are commonly used to treat more serious cases, but may result in additional risks of osteoporosis.

References

  1. W.C. Curr Opin Rheumatol 2010,22:85–90.

  2. Marc A. Judson, MD, Sem Respir Crit care Med 2007;28(1).

Disclosure of Interest None declared

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.