Background Patients with systemic lupus erythematosus (SLE) have accelerated atherosclerosis that can be assessed by the carotid intima media thickness (CIMT) measurement. A prompt hypolipidemic treatment should be a part of the integral management
Objectives To determine the effect of therapy with pravastatin plus ezetimibe on the CIMT in SLE patients.
Patients and Methods Longitudinal, prospective, quasi-experimental trial. Out of 60 SLE patients in whom a carotid ultrasound was performed, we chose 22 with a CIMT >0.7 mm who were administered pravastatin plus ezetimibe during 6 months with determination of CIMT at the end of the study. We performed the following tests: total cholesterol (TC), HDL-cholesterol, LDL-cholesterol, tryglicerides, C-reactive protein (CRP), liver function, muscle enzimes and glucose, basal and at the end of treatment. Statistical analysis: Descriptive statistics and Wilcoxon test were used.
Results There were 22 women with an age of 42±6.3 years, average disease evolution 7.5±6.6 years, of whom, 18 concluded the study. Right basal CIMT was 0.829±0.1448 vs. final 0.688±0.1453, p<0.003; left CIMT was 0.820±0.1312 vs. 0.724±0.1348, p<0.004. Only 3 patients had atherosclerotioc plaques, 2 with an evolution of SLE less than 3 years. TC 208mg/dl vs 168mg/dl, LDL-C 125mg/dl vs. 72mg/dl, p=0.0004. CRP 3.12 vs 2.25 p=0.004. In 2 cases there were gastrointestinal, skin and muscle adverse effects.
Conclusions Treatment with pravastatin plus ezetimibe decreases the CIMT with improvement in the concentration of total cholesterol, LDL-C and CRP levels with good toleration.
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Disclosure of Interest None declared