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AB0598 Thyroiditis in Systemic Lupus Erythematosus: A Case-Control Study
  1. N. Khaldoun1,
  2. A. Abdessemed1,
  3. F. Bougrina1,
  4. R. Chetouane1,
  5. S. Haid1,
  6. F. Rahal1,
  7. T. Mellas1,
  8. I. Megateli1,
  9. S. Azeli1,
  10. S. Lefkir1,
  11. N. Brahimi1,
  12. A. LadjouzeRezig1,
  13. S. Louahchi2
  1. 1Rheumatology, Hôpital BenAknoun
  2. 2Faculty Biological Sciences - USTHB. Alger, Cytokine and NO Synthase Laboratory, Algiers, Algeria

Abstract

Objectives To determine the prevalence of thyroid antibodies (TA): antibodies against thyroid peroxidase (A-TPO) and thyroglobulin (A-TG) in Algerian patients with Systemic Lupus Erythematosus (SLE) and in a healthy population matched for age and sex and To search a dependency between the presence of TA and thyroid dysfunction.

Methods Transversal study carried in BenAknoun hospital between January 2012 and May 2014 on 54 patients with SLE matched for age and sex to a control group of 88 healthy persons. For all patients collect of demographic data, duration of the disease and submitting to clinical examination. Thyroid hormones, TSH and autoantibodies against TPO, TG, DNA, Sm, SS-A, SS-B were measured.

Data analysis: SPSS Software. Significant value for p≤0,05. Using chi2 test to compare %.

Results 54 patients with SLE were included in this study (51 women, 3 males). Their average age was 40±11.7 years, mean disease duration was 10±7 years. The majority of patients (63%) had moderate activity against 37% with high activity. A-TPO were found respectively in 22.22% and 14.77% of lupus and controls (p=0.258), A-TG were found in 23.1% and 11.36% (p=0,066). We found a moderate but not significant link between the absence of A-TPO and the presence of anti Sm (p=0.06) and a significant link between the presence of A-TG and the presence of anti SSB (p=0.049). Subclinical hypothyroidism was found respectively in 9.25% and 2.27% of cases (p=0.062) and sub-clinical hyperthyroidism in 7.4% and 5.68% of cases (p=0.682).

Conclusions In this preliminary study, there was no association between the occurrence of SLE and the presence of TA or subclinical and clinical thyroid dysfunction. But we found a statistical significance association between the presence of A-TG and the presence of antibodies against SS-B.

References

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Disclosure of Interest None declared

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