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AB0551 Assessment of Ovarian Reserve in Premenopausal Patients with Systemic Lupus Erythematosus
  1. A.A. Gasparin,
  2. L. Souza,
  3. M. Sibert,
  4. R.M. Xavier,
  5. R.M.D.S. Chakr,
  6. P.E. Palominos,
  7. J.C.T. Brenol,
  8. O.A. Monticielo
  1. Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil

Abstract

Background The ovarian reserve of patients with systemic lupus erythematosus (SLE) may be affected by disease activity and medication use1,2,3. Studies have found that patients with SLE have similar fertility rates to healthy women of the same age4. Anti-Müllerian Hormone (AMH) is a dimeric glycoprotein which belongs to the transforming growth factor-a family (TGFβ). In the ovary, AMH is secreted by the granulosa cells of growing follicles, and its serum levels have been found to be a reliable marker of ovarian reserve5.

Objectives The goal of the present study was to investigate the ovarian reserve of patients with SLE by measuring anti-Müllerian hormone (AMH) levels, and compare it to that of healthy controls.

Methods His was a case-control study performed on 80 premenopausal women, of whom 40 fulfilled the 1997 American College of Rheumatology (ACR) criteria for SLE and 40 healthy controls paired by oral contraceptive use. Serum concentrations of AMH in peripheral venous blood were measured using a Human AMH ELISA kit (CUSABIO, Wuhan, China).

Results AMH serum levels did not differ between patients with SLE and controls (22.79±17.32 ng/ml versus 21.41±16.22 ng/ml, respectively, p=0.7), even after adjusting for age (21.03±2.074 ng/ml versus 23.97±2.71 ng/ml; p=0.5). AHM levels were not significantly correlated with disease duration (r=0.2; p=0.3), body mass index (BMI) (r=0.2; p=0.2) and disease activity [SLEDAI (r=0.1; p=0.7)] and damage indices [SLICC (r=0.1; p=0.7)]. No associations were found between AMH and ethnicity, current smoking, as well as current or prior use of cyclophosphamide and other immunosuppressants.

Conclusions In this cross-sectional study, women with SLE demonstrated similar AMH levels to healthy controls, suggesting preserved ovarian reserve in this population.

References

  1. Gayed M, Gordon C. Pregnancy and rheumatic diseases. Rheumatology (Oxford). 2007;46:1634-40.

  2. Appenzeller S, Blatyta PF, Costallat LT. Ovarian failure in SLE patients using pulse cyclophosphamide: comparison of different regimes. Rheumatol Int. 2008;28:567-71.

  3. Carp HJA, Selmi C, Shoenfeld Y. The autoimmune bases of infertility and pregnancy loss. Journal of Autoimmunity. 2012; 38:J266 e J274.

  4. Ekblom-Kullberg S, Kautiainen H, Alha P, Helve T, Leirisalo-Repo M, Julkunen H. Reproductive health in women with systemic lupus erythematosus compared to population controls. Scand J Rheumatol. 2009;38(5):375-80.

  5. La Marca A, Spada E, Grisendi V, Argento C, Papaleo E, Milani S, et al. Normal serum anti-Müllerian hormone levels in the general female population and the relationship with reproductive history. Eur J Obstet Gynecol Reprod Biol. 2012;163:180-4.

Disclosure of Interest None declared

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