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AB0549 Outcomes of Vaccination Among Filipino Lupus Patients Seen at the Philippine General Hospital: A One- Year Follow- Up Study
  1. A.T.S. Hernandez,
  2. M.L. Tee,
  3. A.D. Corpuz,
  4. J.L. Hipe,
  5. K.D. Tee
  1. Department of Medicine, University of the Philippines- Philippine General Hospital, Manila, Philippines

Abstract

Background Vaccination of lupus patients has been widely advocated. However, certain factors contribute to a patient's response to the vaccine. Studies have documented that certain medications including the dose, and the patient's disease activity in particular, are factors that affect the response. Although certain reports have studied this occurrence, this has not been particularly addressed in our population, thus our objective of describing the outcomes of influenza and/ or pneumococcal vaccination among Filipino SLE patients seen at the Philippine General Hospital.

Objectives To describe the outcomes of influenza and/ or pneumococcal vaccination among Filipino SLE patients seen at the Philippine General Hospital

Methods We interviewed patients at baseline (two weeks prior to vaccination) to determine the medications they took and their disease activity prior to vaccination. One year after, these patients were followed- up and were asked regarding vaccine- related outcomes such as development of flu, flu- like symptoms, or pneumonia during the interim. All patients consented for this interview.

Results Thirty- one lupus patients were included in the study. Of the 31 patients, 24 received influenza vaccine, 3 received pneumococcal vaccine, and 4 received both. In the influenza group, 5 developed flu or flu- like illnesses and 2 developed pneumonia. Of these two patients, one was managed as an out- patient, while the other was admitted. In the pneumococcal group, none developed pneumonia but 1 suffered from flu. In the group that received both, one developed flu and one expired due to severe sepsis from pneumonia. When these patients with adverse outcomes (n=10) were pooled and were compared with the group who did not suffer any unwanted events (n=21), it was noted that the patients who suffered from adverse outcomes had a longer- standing disease, had higher steroid doses, with a higher baseline disease activity.

Conclusions While various guidelines recommend vaccination among patients with systemic lupus, we have observed that better outcome is seen among patients with low disease activity and those with little or no intake of immunosuppressive agents. These factors should be well- accounted for to ensure the best vaccination outcomes among lupus patients.

References

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Disclosure of Interest None declared

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