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AB0400 High Prevalence of Vitamin D Deficiency and Insufficiency in Patients with Either Rheumatic or Inflammatory Bowel Diseases
  1. V. Bruzzese1,
  2. L. Ridola1,
  3. A. Zullo1,
  4. C. Hassan1,
  5. R. Lorenzetti1,
  6. M.L. Severino1,
  7. P. Scolieri1,
  8. C. Marrese1,
  9. A. Picchianti Diamanti2,
  10. B. Laganà2
  1. 1Nuovo Regina Margherita Hospital, Internal Medicine, Rheumatology and Gastroenterology
  2. 2Immunology and Rheumatology, Sant'Andrea Hospital, Rome, Italy

Abstract

Background Vitamin D deficiency has been reported in patients with chronic inflammatory conditions, such as rheumatic and inflammatory bowel diseases (IBD).

Objectives To assess vitamin D status in patients with either rheumatic or IBD, receiving biologic or disease-modifying antirheumatic drugs (DMARDs) therapies.

Methods In this cross-sectional study, serum vitamin D of consecutive patients were measured. Patients receiving vitamin D supplementation were excluded. Vitamin D levels >30 ng/mL (75 nmol/L) were considered normal, insufficiency is defined as a concentration of 20 to 30 ng/mL (50 to 75 nmol/L), and deficiency when levels were <20 ng/mL (50 nmol/L).

Results A total of 181 patients, including 136 with rheumatic (M/F: 36/100; Median age: 60 years, range 26-84; Rheumatoid arthritis: 87; Psoriatic arthritis: 38; Ankylosing spondilitis: 8; Polymyalgia rheumatica: 3) and 45 with intestinal diseases (M/F: 30/15; Median age: 52 years, range 32-68; Crohn's disease: 24; Ulcerative colitis: 21) were enrolled. A total of 119 patients were receiving biologic therapy and 62 DMARDs. Vitamin D deficiency/insufficiency was detected in as many as 84 (61.8%) and in 34 (75.6%) patients with rheumatic disease or IBD, respectively. IBD patients showed significantly lower vitamin D levels than rheumatological patients (28.7±19.1 vs 22.5±10.3; P<0.01). Among rheumatic disease patients, the prevalence of Vitamin D deficiency (50.7% vs 29.5%; p=0.01), insufficiency (28% vs 11.5%; p=0.02), and deficiency-insufficiency (78.7% vs 41%; p<0.001) was significantly higher in patients receiving biologic therapy than in those treated with DMARDs.

Conclusions Prevalence of Vitamin D deficiency/insufficiency was very high in both rheumatic disease and IBD patients, particularly in those receiving a biologic therapy. Vitamin D levels should be investigated also in IBD patients, the deficiency being even more frequent than in rheumatic disease patients.

Disclosure of Interest None declared

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