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AB0326 The Influence of Long Permanent Remission and Low Disease Activity on the Functional and Radiological Outcomes of Rheumatoid Arthritis
  1. Y.A. Ermakova1,
  2. D.E. Karateev1,
  3. E.L. Luchikhina1,
  4. N.V. Demidova1,
  5. A.V. Smirnov2,
  6. E.L. Nasonov2
  1. 1Department of early arthritis and the prediction of rheumatic diseases
  2. 2V.A. Nasonova Research Institute of Rheumatology, Russian Federation, Moscow, Moscow, Russian Federation

Abstract

Background Disease activity is the main of the factors, which influence on the evolution of rheumatoid arthritis (RA). The timely supression of the disease activity and the remission/low activity support prevents the development of functional and structural disorders in patients with early RA.

Objectives To investigate the influence of long remission/low activity support on the functional and radiological outcomes.

Methods We used the data of long-term Russian project “RADICAL” (Early Arthritis: Diagnostic, Outcomes, Criterions, Aggressive Treatment). 200 patients with early RA (diagnosed for less than two year) according to American College of Rheumatology criteria included in the study from 2003 to 2007 (67,5% RF (+); 57% ACCP (+), 86,5% women, age of 49 [40-58]). Patients followed for 5 years. They were treated by DMARDs including the biologic therapy (24%) according the “tight-control” principle. The radiological investigation of hands and feet, DAS28, HAQ and functional class evaluated every 12 months.

Results From 1 to 5 years of follow-up the number of patients with permanent remission was 28 (group 1), the number of patients with remission/low activity – 26 (group 2), with permanent activity (group 3) – 26, with recurrent RA (group 4) – 120. After 5 years of follow-up HAQ >0,5 has been verified in 7% (group 1), 23% (group 2), 100% (group 3), 62% (group 4), p<0,001. SHS (M±σ) was 37,93±18,98, 35,42±15,11, 69,84±38,70 and 51,45±30,06, respectively, p<0,001.

Conclusions Patients with long permanent remission and low disease activity will benefit with better functional ability and will have less radiological damage.

Disclosure of Interest None declared

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