Stimulation of the soluble guanylate cyclase (sGC) inhibits fibrosis by blocking non-canonical TGFβ signalling

Christian Beyer; Christoph Zenzmaier; Katrin Palumbo-Zerr; Rossella Mancuso; Alfiya Distler; Clara Dees; Pawel Zerr; Jingang Huang; Christiane Maier; Milena L Pachowsky; Andreas Friebe; Peter Sandner; Oliver Distler; Georg Schett; Peter Berger; Jörg H W Distler

doi:10.1136/annrheumdis-2013-204508

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Basic and translational research

Extended report

Stimulation of the soluble guanylate cyclase (sGC) inhibits fibrosis by blocking non-canonical TGFβ signalling

Authors

Christian Beyer Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany PubMed articles Google scholar articles
Christoph Zenzmaier Institute for Biomedical Aging Research, University of Innsbruck, Innsbruck, Austria Department of Internal Medicine, Innsbruck Medical University, Innsbruck, Austria PubMed articles Google scholar articles
Katrin Palumbo-Zerr Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany PubMed articles Google scholar articles
Rossella Mancuso Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany PubMed articles Google scholar articles
Alfiya Distler Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany PubMed articles Google scholar articles
Clara Dees Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany PubMed articles Google scholar articles
Pawel Zerr Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany PubMed articles Google scholar articles
Jingang Huang Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany PubMed articles Google scholar articles
Christiane Maier Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany PubMed articles Google scholar articles
Milena L Pachowsky Department of Trauma and Orthopaedic Surgery, University Erlangen-Nuremberg, Erlangen, Germany PubMed articles Google scholar articles
Andreas Friebe Institute for Physiology, Julius-Maximilians-University Würzburg, Würzburg, Germany PubMed articles Google scholar articles
Peter Sandner Bayer Health Care, Global Drug Discovery—Common Mechanism Research, Wuppertal, Germany Hannover Medical School, Institute of Pharmacology, Hannover, Germany PubMed articles Google scholar articles
Oliver Distler Department of Rheumatology, University Hospital Zurich, Zürich, Switzerland PubMed articles Google scholar articles
Georg Schett Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany PubMed articles Google scholar articles
Peter Berger Institute for Biomedical Aging Research, University of Innsbruck, Innsbruck, Austria PubMed articles Google scholar articles
Jörg H W Distler Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany PubMed articles Google scholar articles

Correspondence to Dr Jörg Distler, Department of Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Ulmenweg 18, Erlangen D-91054, Germany; Joerg.distler{at}uk-erlangen.de

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Citation

Beyer C, Zenzmaier C, Palumbo-Zerr K, et al

Stimulation of the soluble guanylate cyclase (sGC) inhibits fibrosis by blocking non-canonical TGFβ signalling

Annals of the Rheumatic Diseases 2015;74:1408-1416.

Publication history

Received August 22, 2013
Revised January 31, 2014
Accepted February 2, 2014
First published February 23, 2014.

Online issue publication

October 31, 2019

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