Footnotes

• Contributors All authors were responsible for study concept and design, clinical revision and drafting of the manuscript for important intellectual content, and approved the final version of the manuscript to be published. EHV and CLMK were responsible for acquisition of data. EHV, MFP, GW and CLMK were responsible for analysis and interpretation of data. MN and GW obtained funding. GW and CLMK supervised the study.

• Competing interests MN reports having received consultancy fees from Abbott, Roche, Pfizer, MSD, UCB, SOBI and BMS, payment for lectures from Abbott, Roche and Pfizer. TR reports having received payments for lectures from Pfizer and Abbvie. GJW reports having received a research grant from Pfizer (paid to the institution) and payments for lectures from Pfizer and Amgen. CLMK reports having received payment for lectures from Pfizer and Abbvie.

• Patient consent Obtained.

• Ethics approval Medical ethics committee of the Slotervaart Hospital and the Jan van Breemen Research Institute|Reade.

• Provenance and peer review Not commissioned; externally peer reviewed.