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Correspondence response
Response to: ‘Is there a need for new thresholds to define remission and low disease activity by Disease Activity Score 28 calculated with C reactive protein? Real life data from a local registry’ by Favalli et al
  1. Roy Fleischmann,
  2. Eustratios Bananis
  1. Department of Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
  1. Correspondence to Dr Roy Fleischmann, Department of Medicine, University of Texas Southwestern Medical Center, 8144 Walnut Hill Lane, Suite 800, Dallas, TX 75231, USA; RFleischmann{at}arthdocs.com

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We are delighted that the new cut-offs proposed for Disease Activity Score in 28 joints using CRP method (DAS28(CRP))1 have been tested and validated in another cohort.2 We hope that these validations change how DAS28(CRP) is currently being used in daily clinical practice and in clinical trials to determine low disease activity and remission. Furthermore, in our publication,1 we also proposed new cut-offs for Disease Activity Score in 28 joints using ESR method (DAS28(ESR)) that correspond to Simplified Disease Activity Index (SDAI) because we found that DAS28(ESR) underestimates the disease activity compared with SDAI.1 We hope that these new DAS28(ESR) cut-offs can also be tested in other cohorts as well.

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  • Competing interests None.

  • Provenance and peer review Commissioned; internally peer reviewed.

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