Background Novel disease activity indices for primary Sjögren's syndrome, which are EULAR Sjögren's syndrome patient reported index (ESSPRI) and EULAR Sjögren's syndrome disease activity index (ESSDAI) have been recently developed. It is not clear that the relationship between each item of ESSPRI and each domain of ESSDAI.
Objectives To examine correlation between each item of ESSPRI and each domain of ESSDAI.
Methods Sixty-five female patients with primary Sjögren's syndrome who visited our hospital completed ESSPRI and ESSDAI. Forty of them were assessed by these indices more than once at their revisit to our hospital. Average period of time between the assessments was 7.2 months. Multivariate analysis was used to test which domains of ESSDAI correlated with ESSPRI items (dryness, fatigue, and pain).
Results Mean (SD) of ESSPRI and ESSDAI were 4.6 (2.0) and 3.7 (4.3), respectively. There was no correlation between ESSPRI and ESSDAI (r =0.08) as reported previously1, and also no correlation between ΔESSPRI and ΔESSDAI was found (r =0.16). There was no correlation between ESSPRI items and ESSDAI domains. In contrast, Δdryness inversely correlated with Δrenal domain (p=0.015) and Δcutaneous domain (p =0.03), and Δfatigue correlated with Δarticular domain (p =0.037) and Δhematological domain (p =0.009); however, there was no correlation between Δpain and any of ESSDAI domains.
Conclusions Although ESSPRI items did not associate with ESSDAI domains, change in dryness and fatigue correlated with change in some domains of ESSDAI. This finding suggests that extraglandular worsening and improvement in specific domains may affect change in dryness and fatigue symptoms.
Seror R, et al. Arthritis Care Res. 2013;65:1358-1364.
Disclosure of Interest None declared