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AB0533 Lupusqol and Associations with Clinical Measurements of 104 Russian Patients with Lupus (Renaissance)
  1. M. Zavalskaya1,
  2. E. Asseeva1,
  3. S. Soloviev1,
  4. V. Amirdzhanova1,
  5. S. Glukhova2,
  6. E. Nasonov1
  1. 1Intensive care department
  2. 2Department of Statistics, Nasonova Research Institute of Rheumatology, Moscow, Russian Federation

Abstract

Methods A group of 104 SLE inpatients completed the LupusQoL. Demographic (age, sex, marital status,) and clinical variables (disease duration, disease activity, damage) were recorded.

Associations between the 8 LupusQoL domains and age, disease duration, disease activity (SELENA SLEDAI), PGA and damage (SLICC/ACR DaI), sex and marital status were explored using Spearman's correlation coefficients.

Results HRQOL was assessed by 8 scales, poor = 0, good = 100 points. All domains of LupusQoL were impaired, with burden to others (58.9) being the worst affected and intimate relationship (73.5) the least.

The correlations between the LupusQoL domain scores and age (r = -0.03 to -0.21) and disease duration (r= -0.19 to 0.4) were absent or weak. Similarly, there were no significant differences in the LupusQoL scores regarding sex, marital status.

Although there were statistically significant correlations between the scores of the LupusQoL domains and of the SELENA SLEDAI (r= -0.28 to -0.12), the SLICC/ACR DAI (r= -0.36 to -0.23), these were weak of the PGA (r= -0.33 to -0.21).

In our study low levels HRQOL <40 (LupusQol), was associated with the presence of neuropsychiatric systemic lupus erythematosus (NPSLE) lesions (21%), p<0.05, joints lesions (27.27%), p=0.27, skin lesions, rarely in patients with lupus nephritis (9.09%), p<0.05.

Conclusions HRQOL was impaired in our cohort of patients with SLE as assessed by the validated lupus-specific LupusQoL. There were no clinically important associations between the 8 domains of the LupusQoL and demographic variables in the Russian cohort. There were statistically significant correlations between the HRQOL and disease activity, and organ damage in Lupus patient.

Disclosure of Interest None declared

DOI 10.1136/annrheumdis-2014-eular.4885

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