Background Chemokines play an important role in the development of inflammatory conditions and progression of autoimmune disease such as SLE (1, 2). As it is accepted that a combination of biomarkers would be much more useful for diagnosis and monitoring of diseases course than a single biomarker (3) I assume that a suitable combination of chemokines determined simultaneously might be used to monitor the course and progression of SLE.
Objectives The objective of the study was the assessment of the relationships between serum concentrations of selected chemokines in the treated patients with SLE.
Methods In 48 women with SLE and in the control group (29 healthy women) using the commercially available ELISA kits the following chemokines were tested: MCP-1 (CCL2), SDF-1 (CXCL12), IP-10 (CXCL10), IL-8 (CXCL8), RANTES (CCL5), BLC (CXCL13) and the relationships between them were analyzed by the Spearman's correlation coefficient.
Results In SLE patients the investigations revealed a moderate positive correlation between MCP-1 and SDF-1 and moderate negative correlation between MCP-1 and IL-8 and also positive correlation between SDF-1 and IP-10. In the control group any statistically significant correlations were not found.
Conclusions Taking into consideration the lack of associations between serum levels of determined chemokines in the control group it is believed that investigations should be continued in SLE patients, especially before and during therapy, to determine the significance of the obtained results for diagnosis and effectiveness of applied therapy in this disease.
Alzawawy A., et al.:Intern J Rheum Dis 2009; 12:311-318.
Lima G., et al.: Hum Immunol 2007; 68:980-985.
Kong KO., et al.: Clin Exp Immunol 2009; 156:134-140.
Disclosure of Interest None declared
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.