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AB0354 Cardiovascular Risk Factors in Rheumatoid Arthritis: Descriptive Study
  1. R. Hernández1,
  2. S.A. Rodriguez2,
  3. J. Uceda2,
  4. J.L. Marenco2
  1. 1Reumatology
  2. 2Valme Hospital, Seville, Spain

Abstract

Background Patients with rheumatoid arthritis (RA) have an increased cardiovascular morbidity and mortality (CV) remains leading cause of death. The SCORE (Systematic Coronary Risk Evaluation) are tables that allow us estimate the risk of CV death. Routine use with low-risk patients would allow us to identify those individuals in whom measures of both primary and secondary prevention of cardiovascular disease would have a special importance. This in turn would lead to a better functional prognosis of the patient, allowing to try to develop specific prevention strategies of CV mortality.

Objectives To describe the characteristics in terms of risk factors in patients with rheumatoid arthritis (RA) for cardiovascular disease. We calculate SCORE CV mortality risk at 10 years.

Methods Observational study of a case series of patients diagnosed with RA tracking Valme hospital area. We collected all the following variables: Sex, age, smoking habit, systolic blood presure (mm Hg) and total cholesterol (mg/dl). The risk of cardiovascular mortality to 10 years will be determined by the SCORE risk adapted for southern European people.

Results A total of 107 patients diagnosed with RA were reviewed. Baseline characteristics of subjects were: the mean duration of RA was 7.8 years (SD 5.6), 67% were ACPA + (median value 275.9), 62.6% were FR + (median value 97.84). DAS 28 at the time the study was 2.8 (SD 1.2). 82% used DMARD therapy, the most used was MTX and 12% received biological treatments, being the most used etanercept.

Among cardiovascular risk factors we found that 69.5% were obese (BMI >25), 54.7% had dyslipidemia, 41% hypertension, 22.1% were smokers and finally, 13,2% are diagnosed with diabetes mellitus.

Conclusions Although cardiovascular diseases are a major cause of morbidity and mortality in RA, in our sample we find that the median SCORE has a value less than 5 (low risk of cardiovascular mortality to 10) This could be justified by the application of primary and secondary measures of prevention. However, about 25% of patients in this series have a high cardiovascular risk (greater than 5%) which is an important percentage. In some ways this was expected since most of them were obese and had hyperlipidemia, and almost 50% had hypertension. In view of these data, it seems clear we need to develop specific action strategies that allow us to remove the modifiable risk factors (smoking, obesity ...) in order to improve the prognosis of our

References

  1. Wilson PWF, D'Agostino RB, Levy D, Belanger AM, Silbershatz H, Kannel WB. Prediction of Coronary Heart Disease Using Risk Factor Categories. Circulation [Internet]. 1998 May 19 [cited 2013 Sep 20];97(18):1837–47.

  2. Combe B, Landewe R, Lukas C, Bolosiu HD, Breedveld F, Dougados M, et al. EULAR recommendations for the management of early arthritis: report of a task force of the European Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Annals of the rheumatic diseases [Internet]. 2007 Jan [cited 2013 Aug 27];66(1):34–45.

Disclosure of Interest None declared

DOI 10.1136/annrheumdis-2014-eular.3293

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