Background Rheumatoid arthritis is associated with increased morbidity and mortality due to atherosclerotic cardiovascular diseases. Lipoprotein associated phospholipase A2 (Lp-PLA2) is an enzyme of phospholipase A2, it plays important role in inflammation and atherosclerosis. Here in we aimed to evaluate the Lp-PLA2 activity in rheumatoid arthritis patients and compare the Lp-PLA2 activity with carotid intima media thickness (CIMT).
Objectives In this study we aimed to evaluate the Lp-PLA2 activity in rheumatoid arthritis patients and compare the Lp-PLA2 activity with carotid intima media thickness (CIMT).
Methods 25 consecutive patients with rheumatoid arthritis and forty controls (20 patients with type 2 diabetes mellitus (DM) and 20 healthy controls) were included in the study. The fasting blood samples were tested for Lp-PLA2, complete blood count, glucose, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), serum high density lipoprotein cholesterol (HDL-cholesterol), LDL-cholesterol, and total cholesterol. Frozen serum samples were used for analyzing Lp-PLA2. Disease activity was calculated with DAS-28; HAQ score was evaluated in rheumatoid arthritis group. The mean CIMT was calculated in all participants.
Results Lp-PLA2 activity was significantly higher in DM group (P: 0,006) and LDL-cholesterol levels were lower in rheumatoid arthritis and healthy control groups compared with diabetics (p: 0,001 and p: 0,029, respectively). The mean CIMT were significantly higher in patients with type 2 DM (p: 0,047). Lp-PLA2 activity was not increased in rheumatoid arthritis group when compared with healthy controls. However, Lp-PLA2 activity was significantly higher in the diabetic patients than those in the RA group and in the healthy controls. The mean CIMT were not distinct in rheumatoid arthritis group when compared with healthy controls. This result may be associated with low disease activity scores in the patients with rheumatoid arthritis.
Conclusions As a result an Lp-PLA2 activity in RA patients was similar to healthy control group but lower than diabetics. No correlation was determined between CIMT and Lp-PLA2 activity, which may be associated with our RA patients were inactive and under therapy. LpPLA2 activity and CIMT measurement may give more knowledge on large population of RA patients with active disease.
Disclosure of Interest None declared