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AB0159 The Investigation of Blood Micro-Rna Levels in Ankylosing Spondylitis and the Relationship between Disease Activity and Functional Capacity
  1. K. Çoğul1,
  2. A. Biçer2,
  3. S. Balcı3,
  4. S. Akbayır3,
  5. L. Tamer3
  1. 1Department of Physical Medicine and Rehabilitation, Urgup State Hospital, Nevsehir
  2. 2Department of Physical Medicine and Rehabilitation
  3. 3Department of Biochemistry, Mersin University, School of Medicine, Mersin, Turkey

Abstract

Background Ankylosing Spondylitis (AS) is a chronic inflammatory disease which affects axiel and peripheral joints. The relationship between AS and microRNAs (miRNAs) has not been well documented in the literature.

Objectives The objective of this study is to investigate some of the blood miRNA levels in patients with AS, and their correlations between disease activity and functional capacity.

Methods Fifty patients with AS and 42 healty volunteers, total of 92 subjects have been enrolled in the study. The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score, the The Bath Ankylosing Spondylitis Functional Index (BASFI) and The Bath Ankylosing Spondylitis Metrology (BASMI) scores have been calculated. miRNA analysis were carried out by using high capacity real-time Polymerase Chain Reaction (PCR) method.

Results No significant relationship has been found between patients and healty subjects in terms of miRNA expressions. Expressions of miRNA-16-5p, miRNA-451a, miRNA-320a, miRNA-126-3p, miRNA-17-5p, miRNA 146a-5p and miRNA-223-3p were found to be in low levels in patients with AS. Positive correlations between BASDAI and BASFI scores with the expression of miRNA-205-5p have been found in patients with AS.

Conclusions The results of our study have revealed that there was no any relationship between AS and the blood expression of miRNA levels. However, the blood expression of miRNA-205-5p may play a role in terms of disease activity and functional capacity.

Disclosure of Interest None declared

DOI 10.1136/annrheumdis-2014-eular.3529

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