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AB0067 IL-17F Gene Polymorphism Correlated with Longer Disease Duration of Rheumatoid Arthritis Patients
  1. K. Demircan1,
  2. Z.S. Yasar1,
  3. S. Yüksel1,
  4. R. Hasgul1,
  5. H. Cakirbay1,
  6. O. Cemeroglu1,
  7. B. Yanik1,
  8. E.U. Aslan2,
  9. K. Senel2
  1. 1Turgut Ozal University School of Medicine, Ankara
  2. 2Ataturk University Medical School, Erzurum, Turkey


Background Rheumatoid arthritis (RA) is an autoimmune disease that results in chronic systemic inflammatory disorder that may affect many tissues and organs but principally attacks synovial joints. Interleukin-17F (IL-17) is a proinflammatory cytokine and IL17 F gene is an excellent candidate for chronic inflammatory cytokine.

Objectives To investigate the potential association between rheumatoid arthritis and IL17 F gene polymorphism.

Methods We investigated the potential association between rheumatoid arthritis and IL17 F gene polymorphism. 185 RA patients and 50 healthy control subjects were used. We compare IL17 F gene polymorphism with disease activity score, DAS28, Tender joints, Swollen joints, CRP.

Results The polymorphisms of the IL-17F gene were not correlated with susceptibility to RA patients. However, the IL-17F variant was associated with parameters of disease activity, such as number of tender joints, DAS-28-CRP. Moreover, our findings have shown that IL-17F gene polymorphism may be correlated with longer disease duration in patients with RA.

Conclusions Our results showed the relationship between IL-17F gene polymorphisms and severity of RA.


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Disclosure of Interest None declared

DOI 10.1136/annrheumdis-2014-eular.5482

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