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SAT0507 The Analysis of Factors Associated with Treatment Adherence of Gout: A Patient Survey in China
  1. F. Sheng,
  2. W. Fang,
  3. X. Zeng
  1. Division of general internal medicine, Peking Union Medical College Hospital, Beijing, China

Abstract

Background Poor adherence to urate-lowering drugs (ULD) is a common problem in gout patients. Published data indicate that the proportion of non-adherence is 56-83% in western country1–3.

Objectives To investigate treatment adherence of gout and its associated factors in Chinese patients.

Methods A structured survey was carried out by telephone interview in 161 patients recruited from Gout Clinic at Peking Union Medical College Hospital. All patients satisfied the ACR classification criteria for gout, 1977. The treatment adherence was defined as sustained use of urate-lowering drugs (ULD) in the prior 12 months, otherwise non-adherence. The associated factors with treatment adherence were investigated by logistic regression models.

Results The proportion of treatment adherence was 26.5%. 68.3% of non-adherence patients had never used ULD. The factors associated with treatment adherence included frequency of gout flare (OR 1.04, 95% CI 1.00-1.07), serum uric acid levels (OR 1.43, 95% CI 1.08-1.91), and tophi (OR 4.53, 95% CI 1.83-11.24) at baseline, the number of follow-up visits (OR 1.36, 95% CI 1.05-1.75) and a revisit 30 days after the first one (OR 4.11, 95% CI 1.52-11.12). During the interview, patients reported the reasons that caused non-adherence, including worrying about adverse effects (17.7%), quiescence after lifestyle intervention (16.8%) or ULD treatment (13.3%), and lack of education (9.7%). Other causes less than 5% included adverse events, poor efficacy, sick of medicine and preferring traditional Chinese medicine.

Conclusions The treatment adherence of gout was poor. The severity of disease and follow-up frequency were associated with drug adherence.

References

  1. Zandman-Goddard G, Amital H, Shamrayevsky N, Raz R, Shalev V, Chodick G. Rates of adherence and persistence with allopurinol therapy among gout patients in Israel. Rheumatology (Oxford, England) 2013;52:1126-31.

  2. Harrold LR, Andrade SE, Briesacher BA, et al. Adherence with urate-lowering therapies for the treatment of gout. Arthritis research & therapy 2009;11:R46.

  3. Solomon DH, Avorn J, Levin R, Brookhart MA. Uric acid lowering therapy: prescribing patterns in a large cohort of older adults. Annals of the rheumatic diseases 2008;67:609-13.

Disclosure of Interest None declared

DOI 10.1136/annrheumdis-2014-eular.2587

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