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SAT0476 Vitamin D Supplementation in Liver Transplant Patients
  1. J.L. Valero Sanz,
  2. E. Grau Garcia,
  3. C. Molina Almela,
  4. I. Chalmeta Verdejo,
  5. I. Martinez Cordellat,
  6. C. Feced Olmos,
  7. R. Negueroles Albuixech,
  8. L. Gonzalez Puig,
  9. M.L. Muñoz Guillen,
  10. C. Nuñez-Cornejo Piquer,
  11. C. Alcañiz Escandell,
  12. J. Ivorra Cortes,
  13. J.A. Roman Ivorra
  1. Department of Rheumatology, Hospital Universitario y Politécnico La Fe, Valencia, Spain

Abstract

Background Liver transplant patients are at risk of developing osteoporosis and vitamin D deficiency. This deficit can be correlated with an increase in the rate of bone destruction and a decrease in its formation. Intervention and prevention of vitamin D deficiency in transplant patients may be associated with a decrease in PTH and serum beta CTX, reducing bone destruction.

Objectives The objective of this study was study the utility of vitamin D supplementation in patients undergoing liver transplantation in relation to bone destruction rate.

Methods Since January 2012 we collected 54 patients undergoing liver transplantation, where data is available at transplant (month 0) and 6 month follow-up and 12 months after surgery. We collected data on vitamin D and biomarkers of bone resorption and bone formation.

Results The 54 selected patients are 66% men, with a mean age at transplantation of 55 years. Vitamin D, PTH, and beta-CTX P1NP levels are shown in Table 1. In 49 of the 54 patients, a vitamin D supplement was administered (0.266 mg/15days) immediately after surgery, at 6 months (n=46) and 12 months (n=26). Improved vitamin D levels and normalization of the values of beta-CTX and P1NP were observed.

Table 1

Statistical analysis did not yield significant results, mainly due to the low number of samples available in our series.

Conclusions In general, there is a normalization of serum vitamin D levels and biomarkers of bone resorption and bone formation after a year of treatment with vitamin D supplementation after surgery. This study is at an early stage, so the sample size needs to be expanded in order for statistical analysis to provide greater robustness.

Disclosure of Interest None declared

DOI 10.1136/annrheumdis-2014-eular.5072

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