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SAT0465 Osteopenic Syndrome and Atherosclerosis of Extracranial Arteries among Males with Coronary Heart Disease
  1. E. Malyuta1,
  2. P. Korchuganov1,
  3. A. Voronkina1,
  4. T. Raskina2,
  5. J. Averkieva2,
  6. A. Kokov3,
  7. O. Barbarash3
  1. 1City clinical hospital N 3
  2. 2Kemerovo state medical academy
  3. 3Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation

Abstract

Objectives To examine the relationship between atherosclerosis of extracranial arteries and indicators of bone mineral density (BMD) among men with coronary heart disease (CHD).

Methods 74 males with angiographically verified CHD were examined. BMD was assessed by dual energy absorptiometry (densitometer Exsell XR-46, Norland, the USA) with the definition of T-criterion of the proximal femur and lumbar spine (LI-LIV).

Radiopaque selective coronarography and duplex scanning of the extracranial arteries were carried out using “Aloka α-110”. Artery narrowing was considered hemodynamically significant that was more than 50% of its diameter.

The intima-media thickness (IMT) more than 1.0 mm was regarded as carotid atherosclerosis. For quantitative trait results are presented as the median (Me) with interquartile intervals (25%,;75% percentile). Depending on the values of the T-criterion, patients were divided into 2 groups: I - with osteopenic syndrome including directly osteoporosis and subclinical state of “osteopenia” (53 patients), age 59 (52; 68) years; II - with normal BMD (21 patients), age 58 (54; 66) years.

Results The thickness of the intima-media in group I was 1,1 (1,0; 1,2) mm, in group II – 1,0 (0,9; 1,1 mm), p>0,05. IMT more than 1,0 mm identify 68,0% in group I and 47,6% in group II, p>0.05. Defeat of three or more extracranial arteries among patients with osteopenic syndrome occurred more frequently (10,2%), than among patients with normal BMD (5.0%), p>0.05.

Patients I and II groups did not differ for any stenosis (58, 0% and 38.1%, respectively, p>0.05), while severe stenosis (more than 50%) significantly more often detected among patients with osteopenic syndrome (24,2%) compared to the group with normal BMD (5,5%), p<0.05.

The median % of stenosis was 28% (0; 65) in group I and 0 (0; 27,5) in group II, p>0.05.

The weak strength correlation was revealed between the ratio T-criterion of the femoral neck and the presence of left internal carotid artery stenosis (r= -0,3; p<0,05), as well as an indicator of the T-criterion of the femoral neck and IMT (r= -0,32; p<0.01), BMD proximal femur and IMT (r= -0,31; p<0,05).

Conclusions Reduced bone mineral density among men is associated with hemodynamically significant lesion and correlates with the severity of atherosclerosis of extracranial arteries.

These results confirm the likelihood of common pathogenetic mechanisms of osteopenic syndrome and atherosclerotic lesions of the brachiocephalic arteries.

Disclosure of Interest None declared

DOI 10.1136/annrheumdis-2014-eular.4015

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