Background Interstitial lung disease (ILD) is a potentially severe manifestation of patients with systemic sclerosis (SSc). High-resolution computed tomography (HRCT) is the reference test for diagnosis and follow-up.
Objectives Our objective was to analyze the performance of the MRI, a non-ionizing exploration, compared with the HRCT, to assess the extension of SSc-associated ILD.
Methods We retrospectively collected data of patients with different degrees of ILD due to SSc in which a 1.5T chest MRI (using a 15-seconds HASTE sequence) and a HRCT were performed in a maximum interval of one year. A previously validated HRCT score and new MRI score were performed to assess the extension of the ILD. Composite scores were created to make the comparisons. The regression, correlation and anatomical distribution of MRI compared with HRCT were calculated.
Results Twelve patients were studied (11 women). A strong correlation was found between general MRI and total HRCT composite scores (r=0.70, p=0.01) with a significant linear relationship between them (p=0.01); a moderate correlation was observed between the general MRI and the HRCT fibrosis composite scores (r=0.64, p=0.02), also with a significant linear relationship (p=0.03). The distribution of the MRI and the HRCT composite scores was comparable, showing a predominant distribution of ILD findings in the lower zones of both lungs.
Conclusions Compared with HRCT, our new MRI extension score using a 15-second-sequence MRI showed good correlation, significant linear relationship and similar anatomic distribution, suggesting that MRI may be reliable to assess the extension of ILD in SSc patients.
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Disclosure of Interest None declared
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